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open_questions › What resolves this contention: {'position': 'D1-MSNs and D2-MSNs have opposing roles in drug reward and reinforcement - D1-MSNs promote drug seeking via direct pathway activation while D2-MSNs oppose it via indirect pathway', 'supporting_dois': ['10.1038/s41380-025-03004-1', '10.1038/s41380-019-0484-3', '10.1016/j.neubiorev.2016.05.021', '10.1017/S1461145713001570'], 'evidence_strength': 'strong_initial_evidence', 'cite_keys': []} / {'position': 'Both D1 and D2 MSNs show complex, context-dependent activation during drug seeking. D2-MSNs can promote drug seeking under certain conditions, and the dichotomy breaks down with simultaneous calcium imaging', 'supporting_dois': ['10.1038/s44323-025-00059-9', '10.1038/s41467-025-67459-0', '10.3389/fphar.2022.947785', '10.1038/s41386-022-01338-w', '10.3389/fnsyn.2021.734975', '10.1515/nipt-2025-0004', '10.3389/fncir.2025.1516839', '10.3389/fpsyt.2022.835816'], 'evidence_strengt › diff

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© 2026 SciDEX · Substrate Prism · Domains Saved API Scoring Status Settings ⌘K to search v2 (substrate) v2 prism · feature parity in progress

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