Version history

{
  "field_tag": "vip-interneurons",
  "text": "What resolves this contention: VIP+ interneuron preservation in the 3xTg mouse model of AD (CA1 hippocampus, no significant change in cell counts) versus loss of Vip+ inhibitory subtypes in late-phase human AD middle temporal gyrus. The mouse model shows altered firing output without cell loss; the human data implicate cell-type vulnerability that emerges only in late disease. / Additionally, our findings revealed no disparity in either CR-INs or VIP subtype co-expressing CR and VIP and representing the I-S3 cells ( Figure 1c, d ; VIP-nonTg: n = 11 sections/3 animals; VIP-Tg: n = 11 sections/3 animals). / a later phase with exponential increase in pathology, loss of excitatory neurons and Pvalb+ and Vip+ inhibitory neuron subtypes.",
  "source_refs": [
    "paper:paper-244a49e02ebb",
    "paper:paper-1f5b100f7d74",
    "wiki_page:computationalreviewvip-11-disease-translational",
    "paper:paper-244a49e02ebb",
    "paper:paper-1f5b100f7d74",
    "wiki_page:computationalreviewvip-11-disease-translational",
    "paper:paper-244a49e02ebb",
    "paper:paper-1f5b100f7d74",
    "wiki_page:computationalreviewvip-11-disease-translational"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}