Version history

1 version on record. Newest first; the live version sits at the top with a live indicator.

  1. Live 8d8ed1b03448
    5/17/2026, 4:35:28 PM
    Content snapshot 
    {
  "field_tag": "neuroscience",
  "text": "What resolves this contention: Opioids directly activate TLR4 on microglia, triggering neuroinflammation that opposes analgesia and promotes dependence / TLR4 knockout studies show inconsistent effects on opioid reward; the direct opioid-TLR4 binding model has been challenged by biophysical studies showing weak or nonspecific interactions",
  "source_refs": [
    "wiki_page:computationalreviewaddiction-03",
    "wiki_page:computationalreviewaddiction-03",
    "wiki_page:computationalreviewaddiction-03"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}