Version history

{
  "field_tag": "excitatory-recurrence",
  "text": "What resolves this contention: Whether IT-derived inputs in L1 / apical-tuft compartments produce direct measurable excitatory drive onto L5 apical dendrites (yes in V1 looped circuit, no in S1 generically), and whether this difference is area-, target- or selectivity-dependent. / Intratelencephalic L5 pyramidal neurons in mouse S1 drive L1 interneurons but produce no direct local excitatory effect on neighboring L5 apical tuft dendrites — implying L5 IT axons in L1 act on inhibition, not on local L5 apical excitation. / In mouse V1, FF and FB cortico-cortical inputs (largely IT) deliver stronger excitatory synaptic input onto apical tufts of looped L5 neurons than onto non-looped L5 neurons, indicating that IT-derived L1/apical-tuft inputs do drive local L5 apical excitation in a projection-selective manner.",
  "source_refs": [
    "paper:paper-189d92c83cf0",
    "paper:paper-68ebfbe01b0b",
    "wiki_page:computationalreviewrecurrence-02-anatomy-primer",
    "paper:paper-189d92c83cf0",
    "paper:paper-68ebfbe01b0b",
    "wiki_page:computationalreviewrecurrence-02-anatomy-primer",
    "wiki_page:computationalreviewrecurrence-04-translaminar",
    "paper:paper-189d92c83cf0",
    "paper:paper-68ebfbe01b0b",
    "wiki_page:computationalreviewrecurrence-02-anatomy-primer",
    "wiki_page:computationalreviewrecurrence-04-translaminar",
    "paper:paper-189d92c83cf0",
    "paper:paper-68ebfbe01b0b",
    "wiki_page:computationalreviewrecurrence-02-anatomy-primer",
    "wiki_page:computationalreviewrecurrence-04-translaminar",
    "paper:paper-189d92c83cf0",
    "paper:paper-68ebfbe01b0b",
    "wiki_page:computationalreviewrecurrence-02-anatomy-primer",
    "wiki_page:computationalreviewrecurrence-04-translaminar",
    "paper:paper-189d92c83cf0",
    "paper:paper-68ebfbe01b0b",
    "wiki_page:computationalreviewrecurrence-02-anatomy-primer",
    "wiki_page:computationalreviewrecurrence-04-translaminar"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}