What resolves this contention: Inhibitory specificity (Schneider-Mizell 2024, M…

What resolves this contention: Inhibitory specificity (Schneider-Mizell 2024, MICrONS) is reported at the subclass level (PV/SST/VIP) with discrete targeting categories, whereas Ding 2025 reports excitatory like-to-like wiring as a continuous gradient. The two papers therefore frame cortical wiring rules in different topologies (categorical vs continuous), and reconciling them requires asking whether the inhibitory categories themselves correspond to graded distributions if examined at functional-similarity resolution. / By analysing the synaptic output of inhibitory neurons at both the single-cell and subclass levels, we found that inhibitory neurons exhibited widespread target specificity and identified groups of interneurons with similar subclass-specific targeting but with different compartmental targeting. / Specifically, higher-than-average rates of synaptic density (synapses per unit) were associated with highe