What resolves this contention: Sign of net recurrent influence among co-tuned excitatory neurons: V1 photostimulation shows net competition (like-suppresses-like) while vS1 photoablation shows net cooperative amplification (like-amplifies-like). / Targeted 2P optogenetic activation of single excitatory neurons in mouse V1 L2/3 produces, on average, suppression of nearby co-tuned neurons (like-suppresses-like). / In mouse vS1 L2/3 during active touch, photoablating ~10–20 touch-tuned neurons markedly reduces responses in the spared touch population — implying like-amplifies-like via recurrent E→E coupling within feature-specific subnetworks.
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