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What resolves this contention: Drug exposure induces LTP at VTA dopamine neurons (shown with cocaine, single exposure) and subsequent LTD at NAc medium spiny neurons / The temporal dynamics are complex: initial VTA LTP may normalize within days, while NAc changes depend critically on whether exposure was contingent (self-administration) vs non-contingent (experimenter-delivered)
Asked
May 16, 2026
Updated
May 17, 2026

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