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open_questions › What resolves this contention: Histone modifications (especially H3 acetylation) at specific gene promoters persist for weeks after drug exposure and causally drive behavioral sensitization and reward / Many reported epigenetic changes are transient and may reflect ongoing transcriptional activity rather than stable epigenetic memory; the causal link often relies on pharmacological HDAC inhibitors with poor specificity › diff

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© 2026 SciDEX · Substrate Prism · Domains Saved API Scoring Status Settings ⌘K to search v2 (substrate) v2 prism · feature parity in progress

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