Version history

{
  "field_tag": "excitatory-recurrence",
  "text": "What resolves this contention: Whether PV-only optogenetic perturbations are sufficient probes of the ISN regime, or whether they can give misleading non-ISN signatures (and conversely whether they can give ISN-positive signatures in non-ISN networks). / Awake mouse auditory cortex (A1) operates as an ISN: optogenetic inactivation of PV interneurons produces paradoxical increases in IPSCs onto pyramidal cells. / Reliable detection of an ISN regime in realistic cortex requires perturbing a large fraction of inhibitory neurons; PV-only optogenetic perturbations are insufficient and earlier negative results were therefore inconclusive.",
  "source_refs": [
    "paper:paper-5135d667ceac",
    "paper:paper-b70be986ec0e",
    "wiki_page:computationalreviewrecurrence-09-amplification-isn",
    "paper:paper-5135d667ceac",
    "paper:paper-b70be986ec0e",
    "wiki_page:computationalreviewrecurrence-09-amplification-isn",
    "paper:paper-5135d667ceac",
    "paper:paper-b70be986ec0e",
    "wiki_page:computationalreviewrecurrence-09-amplification-isn",
    "paper:paper-5135d667ceac",
    "paper:paper-b70be986ec0e",
    "wiki_page:computationalreviewrecurrence-09-amplification-isn",
    "paper:paper-5135d667ceac",
    "paper:paper-b70be986ec0e",
    "wiki_page:computationalreviewrecurrence-09-amplification-isn",
    "paper:paper-5135d667ceac",
    "paper:paper-b70be986ec0e",
    "wiki_page:computationalreviewrecurrence-09-amplification-isn"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}