Version history

{
  "field_tag": "neuroscience",
  "text": "What resolves this contention: {'position': 'Desensitization-induced receptor upregulation is the primary driver of nicotine dependence', 'supporting_dois': ['10.1016/j.bbr.2017.02.029', '10.3389/fnins.2025.1670883', '10.1111/ejn.70352'], 'cite_keys': []} / {'position': 'Desensitization is a complex process with subtype-specific effects that can be both pro-addictive and potentially therapeutic', 'supporting_dois': ['10.1016/j.alcohol.2009.09.027', '10.1016/j.pbb.2011.07.001', '10.1016/j.ejmech.2026.118679'], 'cite_keys': []}",
  "source_refs": [
    "wiki_page:computationalreviewaddiction-05",
    "wiki_page:computationalreviewaddiction-05",
    "wiki_page:computationalreviewaddiction-05"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}