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What resolves this contention: The ectopic spiking study shows that optogenetic activation of PV+ neurons causes ectopic action potentials from distal axonal sites, generating non-physiological activity patterns. This challenges the interpretation of optogenetic studies that use broad light stimulation of PV+ cells to study circuit function, including studies measuring PV-to-MC inhibition.
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cbfef7137efe — 5/17/2026, 4:35:28 PM (live)
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cbfef7137efe — 5/17/2026, 4:35:28 PM (live)
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