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open_questions › What resolves this contention: Dopamine signals primarily via volume transmission — ultrastructural studies show most DA varicosities lack postsynaptic specializations, and there is a mismatch between DA release sites and DA receptor locations / Dopamine can act via conventional synaptic transmission in certain circuits — recent evidence from single-vesicle electrochemistry and super-resolution imaging shows structured DA synapses in dorsal striatum › diff

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