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What resolves this contention: Whether medial-frontal feedback to mouse V1 directly enhances visual sensory encoding: Daigle et al. find A24b/M2 axons in V1 carry licking- and reward-related rather than sensory-enhancement signals during a discrimination task; Liu et al. find that ACA (a closely overlapping medial-frontal area) input enhances visual encoding in VISp scaled with arousal — discordance may reflect different behavioural states (passive/arousal vs reward-discrimination) and different ACA subregions. / We observe that while A24b/M2-V1are recruited under these conditions, this is not linked to enhancement of neural or behavioral measures of sensory coding. / ACA input enhanced visual encoding in VISp neurons and scaled with behavioral arousal, whereas ORB input shaped behavior-related modulation but reduced high-contrast visual encoding.
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May 16, 2026
Updated
May 17, 2026

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