Version history

{
  "field_tag": "neuroscience",
  "text": "What resolves this contention: Drugs of abuse (especially opioids) cause VTA dopamine neuron disinhibition by reducing GABA input from local interneurons, and this is a primary mechanism for increased dopamine release / Direct excitation of VTA dopamine neurons and modulation of glutamatergic inputs may be equally or more important than disinhibition; the relative contribution of GABAergic vs glutamatergic changes is circuit- and drug-dependent",
  "source_refs": [
    "wiki_page:computationalreviewaddiction-03",
    "wiki_page:computationalreviewaddiction-03",
    "wiki_page:computationalreviewaddiction-03"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}