Version history

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  1. Live fd561e62e89a
    5/17/2026, 4:35:28 PM
    Content snapshot 
    {
  "field_tag": "neuroscience",
  "text": "What resolves this contention: Whether Nav1.1 (Scn1a) is functionally relevant only in PV interneurons or also in SST cells. Yamakawa suggests PV-restricted expression, while Tai et al. demonstrate functional impact on both PV and SST cells. / Nav1.1 expression is largely confined to PV-positive interneurons and not expressed in SST-positive or calretinin-positive cells. / Scn1a haploinsufficiency causes substantial reduction of excitability in both PV and SST interneurons, implying Nav1.1 is functionally relevant in SST cells too.",
  "source_refs": [
    "paper:paper-855d0bdbad3b",
    "paper:paper-8c5838461042",
    "wiki_page:computationalreviewpv-02",
    "paper:paper-855d0bdbad3b",
    "paper:paper-8c5838461042",
    "wiki_page:computationalreviewpv-02",
    "paper:paper-855d0bdbad3b",
    "paper:paper-8c5838461042",
    "wiki_page:computationalreviewpv-02"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}