open
What resolves this contention: Specificity of VIP→SST inhibition vs broader VIP→PV inhibition / VIP interneurons preferentially target SST interneurons, with much weaker connections onto PV cells, defining a specialized VIP→SST disinhibitory motif. / VIP interneurons inhibit both SST and PV interneurons; PV cells receive functional VIP IPSCs that are smaller-amplitude and faster-decaying but consistently present, so the motif is parallel disinhibition rather than exclusively VIP→SST.
Asked
May 16, 2026
Updated
May 17, 2026

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