Version history

{
  "field_tag": "basal-ganglia",
  "text": "What resolves this contention: Hersch et al. (1995) reports a quantitative bias of ipsilateral motor corticostriatal terminals toward D1+ (direct-pathway) spines (65% vs 47%). Doig et al. (2010), using BAC-D1/D2 mice and EM with VGluT1/VGluT2, find no difference in cortical synapse incidence between D1- and D2-MSNs. Species and methodological differences (rat vs mouse, lesion-degeneration vs vGluT immuno) likely contribute, but the disagreement on whether motor cortex preferentially innervates direct-pathway MSNs is unresolved. / Ipsilateral motor corticostriatal afferents were primarily axospinous and significantly more synapsed with D1 than D2-positive spines (65% vs 47%). / We found that the proportion of synapses formed by terminals derived from the cortex and thalamus was similar for both direct and indirect pathway MSNs.",
  "source_refs": [
    "paper:paper-3560afad5b8d",
    "paper:paper-6a6238e2e03c",
    "wiki_page:computationalreviewloops-02",
    "paper:paper-3560afad5b8d",
    "paper:paper-6a6238e2e03c",
    "wiki_page:computationalreviewloops-02",
    "paper:paper-3560afad5b8d",
    "paper:paper-6a6238e2e03c",
    "wiki_page:computationalreviewloops-02"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}