Version history

{
  "field_tag": "astrocytes",
  "text": "What resolves this contention: Reactive astrocytes can be meaningfully classified into neurotoxic A1 and neuroprotective A2 subtypes defined by distinct gene signatures; A1 astrocytes are induced by IL-1α/TNF/C1q, lose supportive functions, and kill neurons and oligodendrocytes vs. Binary A1/A2 divisions are insufficient and potentially misleading; reactive astrocytes exist along a multidimensional spectrum and should be characterized by multiple molecular and functional parameters with multivariate statistics / A1 astrocytes lose normal supportive functions and instead induce death of neurons and oligodendrocytes. / Binary divisions of reactive astrocytes into A1 versus A2 categories are insufficient, and research should instead assess multiple molecular and functional parameters with multivariate statistics.",
  "source_refs": [
    "paper:4e417ba1-8ca9-4066-b80f-30ac62a536e4",
    "paper:e34924e9-6767-42c2-aec6-a464c23d03c7",
    "wiki_page:computationalreviewastrocytes-12",
    "paper:4e417ba1-8ca9-4066-b80f-30ac62a536e4",
    "paper:e34924e9-6767-42c2-aec6-a464c23d03c7",
    "wiki_page:computationalreviewastrocytes-12",
    "paper:paper-7df182e5860f",
    "paper:4e417ba1-8ca9-4066-b80f-30ac62a536e4",
    "paper:e34924e9-6767-42c2-aec6-a464c23d03c7",
    "wiki_page:computationalreviewastrocytes-12",
    "paper:paper-7df182e5860f",
    "paper:4e417ba1-8ca9-4066-b80f-30ac62a536e4",
    "paper:e34924e9-6767-42c2-aec6-a464c23d03c7",
    "wiki_page:computationalreviewastrocytes-12",
    "paper:paper-7df182e5860f"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}