Version history

{
  "field_tag": "excitatory-recurrence",
  "text": "What resolves this contention: Whether Ntsr1-Cre labels a homogeneous L6-CT class. The Cre-line characterization paper treats Ntsr1-Cre+ neurons as a clean projection-class identifier (CT only, ~90% penetrance), while the awake-recording paper shows the same Cre-defined population contains functionally distinct subpopulations (whisking-modulated, suppressed, sparse, silent) — i.e., a single Cre line does not isolate a functionally uniform projection class. / We conclude that Cre-expression is limited to a specific type of pyramidal neuron: CT. However, it appears as not all CT neurons are Cre-expressing; there are indications that the penetrance of the gene is about 90%. We demonstrate the utility of assigning a specific identity to individual neurons by determining that the CT neurons are potently modulated by acetylcholine acting on both nicotinic and muscarinic acetylcholine receptors. / Their spiking patterns were",
  "source_refs": [
    "paper:paper-6dee72af1f39",
    "paper:paper-e29820b466b8",
    "wiki_page:computationalreviewrecurrence-01-introduction",
    "paper:paper-6dee72af1f39",
    "paper:paper-e29820b466b8",
    "wiki_page:computationalreviewrecurrence-01-introduction",
    "paper:paper-6dee72af1f39",
    "paper:paper-e29820b466b8",
    "wiki_page:computationalreviewrecurrence-01-introduction",
    "paper:paper-6dee72af1f39",
    "paper:paper-e29820b466b8",
    "wiki_page:computationalreviewrecurrence-01-introduction",
    "paper:paper-6dee72af1f39",
    "paper:paper-e29820b466b8",
    "wiki_page:computationalreviewrecurrence-01-introduction",
    "paper:paper-6dee72af1f39",
    "paper:paper-e29820b466b8",
    "wiki_page:computationalreviewrecurrence-01-introduction"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}