Version history

{
  "field_tag": "basal-ganglia",
  "text": "What resolves this contention: If TAN pauses are driven equally by cortical and thalamic afferents (Cell Rep 2019), the historical view of TAN pauses as a striatal echo of dopaminergic reward prediction error is hard to maintain. The PNAS 2024 study directly demonstrates this dissociation; older interpretations equating TAN pause with RPE need revision. / There is a mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors. / Cholinergic transmission at muscarinic synapses in striatum is driven equally by cortical and thalamic inputs, suggesting parallel rather than RPE-locked drive.",
  "source_refs": [
    "paper:paper-50abfd885e9f",
    "paper:paper-6322989fbe9a",
    "wiki_page:computationalreviewloops-04",
    "paper:paper-50abfd885e9f",
    "paper:paper-6322989fbe9a",
    "wiki_page:computationalreviewloops-04",
    "paper:paper-50abfd885e9f",
    "paper:paper-6322989fbe9a",
    "wiki_page:computationalreviewloops-04"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}