Version history

{
  "field_tag": "excitatory-recurrence",
  "text": "What resolves this contention: Both studies attribute t-LTD at L2/3-L2/3 horizontal synapses to postsynaptic NMDARs, but disagree on subunit identity (GluN2B vs no claim) and the locus question for vertical L4-L2/3 (presynaptic NMDAR-dependent presynaptic expression vs postsynaptic GluN2C/D dependence) — implying overlapping but distinct molecular accounts of vertical-vs-horizontal t-LTD at the same postsynaptic cell. / Moreover, whereas t-LTD at vertical inputs requires presynaptic NMDA receptors and is expressed presynaptically, using paired recordings we find that t-LTD at horizontal inputs requires postsynaptic NMDA receptors and is expressed postsynaptically. / GluN2C/D antagonists did not block t-LTD at horizontal cross-columnar layer 2/3-to-layer 2/3 synapses, which was blocked by a GluN2B antagonist instead.",
  "source_refs": [
    "paper:paper-4dc12b2ece86",
    "paper:paper-673cb5de6c80",
    "wiki_page:computationalreviewrecurrence-12-plasticity",
    "paper:paper-4dc12b2ece86",
    "paper:paper-673cb5de6c80",
    "wiki_page:computationalreviewrecurrence-12-plasticity",
    "paper:paper-4dc12b2ece86",
    "paper:paper-673cb5de6c80",
    "wiki_page:computationalreviewrecurrence-12-plasticity"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}