Version history

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  1. Live e839ebef0977
    5/17/2026, 4:35:28 PM
    Content snapshot 
    {
  "field_tag": "neuroscience",
  "text": "What resolves this contention: Whether PV interneuron dysfunction in Dravet syndrome is permanent or transient. Tai et al. show substantial reduction at one time point; Favero et al. demonstrate recovery, suggesting a developmental window. / Scn1a haploinsufficiency causes substantial, persistent reduction of excitability in PV and SST interneurons in Dravet syndrome mice. / Fast-spiking interneuron dysfunction in Scn1a+/- mice is transient, occurring during a developmental window with recovery by P35.",
  "source_refs": [
    "paper:paper-26eb18eb4bf8",
    "paper:paper-855d0bdbad3b",
    "wiki_page:computationalreviewpv-02",
    "paper:paper-26eb18eb4bf8",
    "paper:paper-855d0bdbad3b",
    "wiki_page:computationalreviewpv-02",
    "paper:paper-26eb18eb4bf8",
    "paper:paper-855d0bdbad3b",
    "wiki_page:computationalreviewpv-02"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}