Version history

{
  "field_tag": "vip-interneurons",
  "text": "What resolves this contention: Different upstream regulators converge on VIP-IN dysfunction (MeCP2 in Rett vs TCF4 in psychiatric risk), with different reported effects (cell-autonomous activity changes vs density and connectivity changes). Whether all converge on a shared VIP cellular phenotype or on distinct mechanisms is unresolved. / In addition, ~80% of VIP interneurons expressed MeCP2, suggesting a previously unappreciated potential role for this signaling pathway in VIP interneuron development and function. / Psychiatric risk gene Transcription Factor 4 (TCF4) regulates the density and connectivity of cortical interneurons.",
  "source_refs": [
    "paper:paper-4effa559f79e",
    "paper:paper-bcba2772b0e0",
    "wiki_page:computationalreviewvip-11-disease-translational",
    "paper:paper-4effa559f79e",
    "paper:paper-bcba2772b0e0",
    "wiki_page:computationalreviewvip-11-disease-translational",
    "paper:paper-4effa559f79e",
    "paper:paper-bcba2772b0e0",
    "wiki_page:computationalreviewvip-11-disease-translational"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}