{
"title": "Resolve: What evidence would resolve: Here we report that in neurons L-lactate stimulates the expression of synaptic plasticity-related genes such as Arc, c-Fos, and Zif268 through a mechanism involving NMDA receptor activity and",
"abstract": "Analysis proposal generated from a review evidence gap: What evidence would resolve: Here we report that in neurons L-lactate stimulates the expression of synaptic plasticity-related genes such as Arc, c-Fos, and Zif268 through a mechanism involving NMDA receptor activity and its down?",
"proposer_ref": "persona:persona-jerome-lecoq",
"review_ingest": {
"schema": "scidex-computational-review-package-ingest@v1",
"source_url": "https://github.com/AllenNeuralDynamics/ComputationalReviewAstrocytes/blob/1a55da0634a3bc04e5688792ed12141ce271d28e/evidence/section_04_evidence_package.json",
"review_repo": "ComputationalReviewAstrocytes",
"section_ref": "wiki_page:computationalreviewastrocytes-04",
"source_path": "evidence/section_04_evidence_package.json",
"source_review_proposal_ref": "analysis_proposal:anprop-af91b1d59aed"
},
"source_gap_ref": "open_question:oq-75b955a5af87",
"methods_summary": "Mine and synthesize evidence relevant to What evidence would resolve: Here we report that in neurons L-lactate stimulates the expression of synaptic plasticity-related genes such as Arc, c-Fos, and Zif268 through a mechanism involving NMDA receptor activity and its down?",
"expected_runtime": "agent-batched literature and evidence synthesis",
"generation_trigger": "from-gap",
"required_data_refs": [
"wiki_page:computationalreviewastrocytes-04"
],
"proposer_binding_id": "jerome-lecoq-gbo-neuroscience"
}