All protein_designs
- Engineered LRRK2 kinase-domain inhibitor scaffold
Scaffolded peptide inhibitor of LRRK2 kinase activity; competes with ATP-binding site, type-1 inhibitor mode.
- Huntingtin polyQ-tract recognizer
Binder selective for polyQ tracts >35 repeats; targets mutant HTT for selective degradation via PROTAC linker.
- TDP-43 N-terminal stabilizer
Stabilizer for the TDP-43 N-terminal dimerization interface; rescues nuclear localization in iPSC-MN model.
- α-Synuclein aggregation inhibitor
Designed mini-binder against the α-synuclein NAC region; reduces in vitro aggregation kinetics 4-fold.
- Anti-Aβ42 binder de novo
De novo binder targeting the Aβ42 protofibril N-terminus; designed via RFdiffusion + ProteinMPNN, validated by AF2 confidence.
- Test
MKVITLAFGTAVAGAGFAAQVPTVAFTPADQQAVDDFVQKVASLSEKQYE
- TREM2 Variant Design v3 — R186K/D87N/T96I Triple Mutant (Optimized)
phospholipid membrane
- TREM2 Variant Design v2 — R186K/D87N Dual Mutant
phospholipid membrane
- TREM2 Variant Design v1 — Wild-type Reference
phospholipid membrane
- TREM2 Ectodomain Variant — AlphaFold Base
MEPLRGLLVLAGLAFWHLRGGWAPGALLLWSLGPSLGRAHSGPASCQLLACSLSTLAALCASCVLWVVSTALLFLLLLSLAALQLWQWGVAPSRQGPA
- TREM2 Ectodomain Variant — AlphaFold Base
MEPLRGLLVLAGLAFWHLRGGWAPGALLLWSLGPSLGRAHSGPASCQLLACSLSTLAALCASCVLVVVSTALLFLLLLSLAALQLWQRGVAPSRQGPA
- TREM2 Ectodomain Variant — AlphaFold Base
MEPLRGLLVLAGLAFWHLRGGWAPGALLLWSLGPSLGRAHSGPASCQLLACSLTTLAALCASCVLVVVSTALLFLLLLSLAALQLWQRGVAPTLQGPA
- TREM2 Ectodomain Variant — AlphaFold Base
- TREM2 Ectodomain Variant — Binding Optimized
rosetta_interface_design
- TREM2 Ectodomain Variant — Stability Optimized
- TREM2 Ectodomain Variant — Binding Optimized
MEPLRPPGAWVLlalllgsaegstceedvddtfldtafqgvltfqrgdsvvtgalhcqptarcqmssqeqtlyqkvslyvragkrarvqgipvsvgeggmlhlidylafavnmskgtytegllayceesssspmsahpprarlvkfhlpptttvqvlpqfqklpetggslvylv
- TREM2 Ectodomain Variant — Stability Optimized
MEPLRPPGAWVLlalllgsaegstceedvddtfldtafqgvltfqrgdsvvtgalhcqptarcqmssqeqtlyqkvslyvragkrarvqgipvsvgeggmlhlidylafavnmskgtytegllayceesssspmsahpprarlvkfhlpptttvqvlpqfqklpetggslvylv
- TREM2 Ectodomain Variant — AlphaFold Base
MEPLRGPHSLWALALCLLTSAGPGAQKVEVETTNPCRLDGRELSDTFYGPMTPEDQRTVSLGGDLGPGILSRHGLDSSVPPTTAEMQALGFRLEEASGPPCRESG
- TREM2 Ectodomain Variant — AlphaFold Base
MEPLRGPHSLWALALCLLTSAGPGAQKVEVETTNPCRLDGRELSDTFYGPMTPEDQRTVSLGGDLGPGILSRHGLDSSVPPSTAEMQALGFRLEEASGPPCRESG
- TREM2 Ectodomain Variant — AlphaFold Base
MEPLRGPHSLWALALCLLTSAGPGAQKVEVETTNSCRLDGRELSDTFYGPMTPEDQRTVSLGGDLGPGILSRHGLDSSVPPSTAEMQALGFRLEEASGPPCRESG
- TREM2 Ectodomain Variant — AlphaFold Base
- TREM2 Ectodomain Variant — Stability Optimized
MEPLRPPHLWAVLLLLGLRLQPRWAGSELQCKEVLKCTCNGSLECLQPRFQNSSKCSWWPAGRRCSCQVKGSVLGEPRPRPV
- TREM2 Ectodomain Variant — Binding Optimized
MEPLRPPHLWAVLLLLGLRLQPRWAGSELQCKEVLKCTCNGSLECLQPRFQNSSKCSWWPAGRRCSCQVKGSVLGEPRPRPV
- TREM2 Ectodomain Variant — Stability Optimized
- TREM2 Ectodomain Variant — Binding Optimized
rosetta_interface_design