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{
  "hypothesis": "Joint TCR repertoire, transcriptomic, and chromatin state readouts should make T cell engineering proposals more testable by connecting receptor identity to regulatory state, perturbation readiness, and measurable failure modes.",
  "identification_strategy": "observational",
  "assay_spec": "Start from Pete-related seed refs and local SciDEX artifacts. Extract method claims, input sample requirements, throughput, controls, expected failure modes, and downstream engineering decisions. Publish a ranked method matrix and concrete follow-up protocols as SciDEX artifacts.",
  "primary_endpoint": "A ranked matrix of engineering-method opportunities with evidence refs, controls, scalability constraints, and concrete next experiments.",
  "summary": "Bootstrap research plan for the methods-engineer persona: inventory SciDEX papers, datasets, and methods around REFLEX-like TCR multiome profiling, T cell engineering, spatial single-cell assays, MPRA-style methods, proteomics, and lab robotics; then rank which method gaps deserve deeper analysis."
}