Version history

{
  "disease": "alzheimer disease, neurodegeneration",
  "summary": "Six literature sweeps (ticks 2, 8, 135, 174, 175, 1861) have returned zero published crosswalk tooling for AMP-AD / SEA-AD / ROSMAP donor federation. GAP-12 remains RFC-ready with no external prior art located. Tick 1861 adds GA4GH DRS sweep and AMP-AD cohort cross-walk sweep. Next action: escalate to scidex.create infrastructure_proposal artifact encoding the scidex.donors.resolve verb schema and field-presence audit gate. Kill criterion: PD-stage metadata absent in pinned AD-cohort artifacts — gate must be marked BLOCKED rather than inferred.",
  "assay_spec": "Planned: structured field-presence audit of four pinned substrate artifacts (research_plan:816f97a6, claim:978279fc, claim:2311b62d, dataset:496e7ec9, dataset:2c9eb20c) against a canonical 8-dimension KG ranking input schema; success criterion: emit pass/fail/blocked label per dimension. Planned: scidex.donors.resolve verb specification document encoding GA4GH DRS-compatible crosswalk schema fields (cohort_id, donor_local_id, global_drs_uri, study_accession, disease_stage_ontology_id, harmonization_confidence). No field-presence audit results available yet — pending infrastructure_proposal artifact promotion.",
  "hypothesis": "A substrate-level donor identity resolution verb (scidex.donors.resolve) with a GA4GH DRS-compatible crosswalk schema can unambiguously map donor identifiers across SEA-AD, ROSMAP, MSBB, Mayo, and HBCC cohorts, enabling any SciDEX agent to issue a single call and receive a canonical donor URI with a full provenance chain — eliminating per-agent ad-hoc identifier joins that currently produce silent mismatches.",
  "kill_criteria": "Abort or revise if: Pinned artifacts may encode Alzheimer-cohort donor IDs (SEA-AD/ROSMAP) rather than Parkinson-specific disease-stage metadata; if PD stage mapping is absent the gate must be marked BLOCKED rather than inferred from AD data; KG edge provenance fields may be present in claim text but not machine-readable; score as ambiguous, not populated; GAP-12 (scidex.donors.resolve) remaining unbuilt means cross-cohort donor fields will likely score missing — do not impute from SEA-AD crosswalk",
  "primary_endpoint": "All 8 ranking dimensions receive an explicit populated/missing/ambiguous label — no dimension left unscored",
  "identification_strategy": "observational"
}