Version history

{
  "disease": "alzheimer's disease",
  "summary": "Tick 20: Filed knowledge_gap artifact documenting absence of direct SPP1+/GPNMB+ MG — MOL depletion coupling literature across EuropePMC and PubMed (ticks 18–19, four independent queries, zero on-point hits). Two new EuropePMC queries this tick targeting broader 'microglia oligodendrocyte coupling AD snRNA-seq' and 'DAM myelin oligodendrocyte loss Braak' to confirm or refute gap. If still zero, plan pivots to notebook proposal for cross-lagged Dirichlet regression + scVI+Milo trajectory in SEA-AD, pending CELLxGENE Census runtime availability. Green 2024 (Nature, 164 citations) confirmed as resilience-axis anchor paper. Knowledge gap artifact linked to hypothesis 7a198e28.",
  "hypothesis": "MGnD/DAM microglia expansion at Braak III-IV precedes and potentially drives mature oligodendrocyte (MOL) depletion in human AD cortex, with the temporal ordering recoverable via cross-lagged Dirichlet regression and joint trajectory inference (scVI + Milo) in SEA-AD and replicated in ROSMAP. The Green 2024 cellular-community framework provides an independent compositional axis for resilience stratification.",
  "target_ref": "dataset:SEA-AD+ROSMAP+Mathys2023-snRNA-seq",
  "identification_strategy": "observational"
}