Version history

{
  "hypothesis": "Enhancer-design models such as sequence-to-expression predictors should be ranked against cell-type objectives grounded in reliable atlas labels and measurement constraints, not only generic model scores.",
  "identification_strategy": "observational",
  "assay_spec": "Start from Trygve-related seed refs and local SciDEX artifacts. Build a benchmark map linking cell types, target expression patterns, candidate enhancer models, available validation data, and failure modes. Publish evaluation criteria and candidate benchmark artifacts back to SciDEX.",
  "primary_endpoint": "A benchmark-ready list of enhancer-design objectives with linked atlas refs, model assumptions, validation datasets, and known confounders.",
  "summary": "Bootstrap research plan for the enhancer-modeling persona: collect SciDEX artifacts about Allen cell atlases, enhancer model families, benchmark datasets, and neuronal cell-type expression objectives; identify where model evaluation is currently under-specified."
}