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30 results
- Hypothesis H7: Enteric Nervous System Alpha-Synuclein Propagation Blocker via Gut Barrier Restoration
Alpha-Synuclein Propagation Blocker via Gut Barrier Restoration starts from
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Alpha-Synuclein Aggregates Drives Non-Cell-Autonomous Neurodegeneration > **Status**: ✅ Validated
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alpha-synuclein modulates DNA repair. First, alpha-synuclein colocalizes with
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alpha-synuclein (SNCA)—converge at the presynaptic vesicle as a functional
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alpha-synuclein inclusions. A shared misfolded-alpha-synuclein seeding axis
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alpha-synuclein feed-forward injury **Hypothesis Type**: cross_disease_synthesis
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- Hypothesis TFEB Activation to Restore Lysosomal Function in Parkinson's Disease Alpha-Synuclein Clearance
alpha-synuclein protein aggregates (Lewy bodies) in dopaminergic neurons of the substantia
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alpha-synuclein antibodies. Strong alpha-synuclein immunoreactivity was found in glial
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alpha-synuclein, neuroinflammation, and oxidative stress mediated by reactive oxygen
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alpha-synuclein, iron compounds and iron-containing proteins in the structures
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alpha-synuclein can propagate from the enteric nervous system to the CNS via the vagus
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- Paper Staged Screening Identifies People with Biomarkers Related to Neuronal Alpha-Synuclein Disease.
alpha-synuclein aggregation. We evaluated the performance of a staged
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alpha-synuclein lysosomal rupture, or TDP-43 proteinopathy is the chief
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- Hypothesis TFEB Activation to Restore Lysosomal Biogenesis in Parkinson's Disease Dopaminergic Networks
alpha-synuclein oligomers and Lewy bodies that disrupt dopaminergic neurotransmission
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alpha-synuclein aggregation in parallel. ## Limitations and Challenges Several challenges
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alpha-synuclein, and TDP-43 can adopt conformations that corrupt
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alpha-synuclein into Lewy bodies. First described by James Parkinson
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alpha-synuclein aggregates in cell models 3. PIKFYVE regulates endosomal
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Alpha-synuclein (alpha-syn) is an abundant neuronal protein expressed
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alpha-synuclein. Recent research has proposed that alpha-synuclein pathology
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Alpha-synucleins and beta-synucleins are present predominantly in the inner plexiform layer, whereas gamma-synuclein is in the nerve fiber layer. In transgenic mice overexpressing
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Alpha-synuclein aggregates in Parkinson's disease and TDP-43 aggregates
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- Wiki Validated Hypothesis: Inhibiting Heparan Sulfate Proteoglycan Receptor-Mediated Neuronal Tau Uptake
Alpha-synuclein aggregates in Parkinson's disease and TDP-43 aggregates
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Alpha-synuclein aggregates further disrupt TFEB nuclear translocation. TFEB overexpression
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alpha-synuclein preformed fibrils (PFFs) cross the blood-brain barrier
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- Hypothesis m6A Hypermethylation of SNCA mRNA Stabilises Alpha-Synuclein Transcript and Promotes Lewy Pathology
alpha-synuclein protein levels, and lowers the concentration threshold for protein
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alpha-synuclein stress. Falsifiable prediction: A biased TREM2 agonist that
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alpha-synuclein, amyloid β (beta) and τ (tau) proteins aggregation
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- Paper beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor.
Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti
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alpha-synuclein (αSyn) binding and fibrillization. The resultant αSyn oligomers
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