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Alpha-Synuclein Aggregates Drives Non-Cell-Autonomous Neurodegeneration > **Status**: ✅ Validated
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alpha-synuclein inclusions. A shared misfolded-alpha-synuclein seeding axis
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alpha-synuclein feed-forward injury **Hypothesis Type**: cross_disease_synthesis
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alpha-synuclein lysosomal rupture, or TDP-43 proteinopathy is the chief
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alpha-synuclein, and TDP-43 can adopt conformations that corrupt
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alpha-synuclein into Lewy bodies. First described by James Parkinson
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- Wiki Validated Hypothesis: Inhibiting Heparan Sulfate Proteoglycan Receptor-Mediated Neuronal Tau Uptake
Alpha-synuclein aggregates in Parkinson's disease and TDP-43 aggregates
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alpha-synuclein stress. Falsifiable prediction: A biased TREM2 agonist that
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Alpha-Synuclein Aggregates Drives Non-Cell-Autonomous Neurodegeneration (score 0.822; target
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Alpha-Synuclein Aggregates Drives Non-Cell-Autonomous Neurodegeneration (score 0.822; target
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alpha-synuclein fibrils, or pathological tau conformers) - An Fc domain
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alpha-synuclein (SNCA), and FUS, ESM-2 can compute the log-likelihood
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alpha-synuclein species (via anti-α-synuclein antibodies), depending on the specific
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synuclein accumulation in Parkinson's disease. *(2019; Mov Disord; [PMID:30788890](https://pubmed.ncbi.nlm.nih.gov/30788890/); confidence: medium)* 15. Functional screening of lysosomal storage disorder genes identifies modifiers of alpha
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synuclein accumulation in Parkinson's disease. *(2019; Mov Disord; [PMID:30788890](https://pubmed.ncbi.nlm.nih.gov/30788890/); confidence: medium)* 15. Functional screening of lysosomal storage disorder genes identifies modifiers of alpha
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Alpha-Synuclein](/wiki/genes-snca) - [PINK1](/wiki/genes-pink1) - [Parkinson's Disease](/wiki/diseases-parkinson-disease) - [Lysosomal
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Alpha-Synuclein Pathology and Neurodegeneration through PARP1 Activation in a Mouse
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alpha-synuclein toxicity and oxidative stress. Post-mortem studies reveal
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Alpha-synuclein, the primary component of Lewy bodies in PD, is degraded
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alpha-synuclein models without compromising general immune surveillance. **Confidence:** 0.71 --- ### Hypothesis
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alpha-synuclein seeding assays ## Skills in This Category | Skill | Upstream
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alpha-synuclein, TDP-43, FUS, or other aggregate-prone proteins
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alpha-synuclein pathology, Huntington's disease, and various tauopathies. The modular
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alpha-synuclein aggregation modulators ## Skills in This Category | Skill | Upstream
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alpha-synuclein, and TDP-43 have proven difficult to screen
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alpha-synuclein in Parkinson's disease, TDP-43 in ALS and frontotemporal
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alpha-synuclein design ## Skills in This Category | Skill | Upstream Path
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