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All 7 Hypotheses 1 Papers 1 Wikis 1 Gaps 1 Colliders 0 Debates 1 Bounties 0 Missions 1 Work packets 1 Genes 0 Diseases 0 Phenotypes 0 Gene ontology 0

✓ Hypotheses 1 + Papers 1 + Wikis 1 ✓ Gaps 1 + Colliders 0 + Debates 1 + Bounties 0 + Missions 1 + Work packets 1 + Genes 0 + Diseases 0 + Phenotypes 0 + Gene ontology 0

30 results

Hypothesis Age-related neuroinflammation mimics early Alzheimer's disease pathology rel 2.20

Alzheimer's disease pathology starts from the claim that modulating

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Hypothesis Real-time closed-loop transcranial focused ultrasound targeting PV interneurons with API-integrated biomarker validation in Alzheimer's disease rel 1.60

Alzheimer's disease starts from the claim that modulating PVALB

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Hypothesis Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via astrocytic calcium signaling and potassium buffering in Alzheimer's disease rel 1.60

Alzheimer's disease starts from the claim that modulating AQP4

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Hypothesis Real-time closed-loop transcranial focused ultrasound targeting PVALB interneurons with continuous gamma oscillation feedback monitoring for precision neuromodulation in Alzheimer's disease rel 1.60

Alzheimer's disease starts from the claim that modulating PVALB

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Hypothesis Optogenetic restoration of hippocampal gamma oscillations via channelrhodopsin-2 expression in PV interneurons for Alzheimer's disease treatment rel 1.60

Alzheimer's disease treatment starts from the claim that modulating

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Hypothesis Hippocampus ages transcriptionally faster than cerebellum, defining a regional vulnerability axis conserved across species rel 1.50

Alzheimer's disease can redirect a disease-relevant process. The original

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Hypothesis Hippocampal-Cortical Transcriptomic Divergence Reveals Accelerated Neurodegeneration-Like Signatures rel 1.50

Alzheimer disease can redirect a disease-relevant process. The original

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Hypothesis CD8+ T-Cell Perforin Pathway as Driver of Neuronal Pyramid Loss rel 1.40

Alzheimer's disease, Parkinson's disease can redirect a disease

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Hypothesis ELF2-Mediated OPC Epigenetic Drift Drives Region-Dependent Myelin Dysfunction rel 1.40

Alzheimer disease can redirect a disease-relevant process. The original

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Hypothesis Age-driven synaptic gene silencing precedes neuronal loss in vulnerable brain regions rel 1.40

Alzheimer's disease can redirect a disease-relevant process. The original

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Hypothesis Myelin Breakdown-Amyloid Interaction Amplifies Cortical Aging-Neurodegeneration Overlap rel 1.40

Alzheimer disease can redirect a disease-relevant process. The original

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Hypothesis SPP1+ DAM as Source of Autoimmunity in Neurodegeneration rel 1.40

Alzheimer's disease can redirect a disease-relevant process. The original

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Hypothesis Astrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate rel 1.40

Alzheimer's disease, Parkinson's disease can redirect a disease

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Hypothesis APOE and TREM2 interact to modulate age-dependent microglial dysfunction rel 1.40

Alzheimer's disease can redirect a disease-relevant process. The original

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Hypothesis C1q-TREM2 Competition for Phosphatidylserine as Pruning Checkpoint rel 1.40

Alzheimer's disease can redirect a disease-relevant process. The original

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Hypothesis Hippocampal mitochondrial dysfunction accelerates with age and drives regional AD vulnerability rel 1.40

Alzheimer's disease can redirect a disease-relevant process. The original

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Hypothesis TREM2-APOE4 Axis Drives Metabolic Inflexibility in DAM rel 1.40

Alzheimer's disease can redirect a disease-relevant process. The original

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Hypothesis Targeting AQP4 Sumoylation to Enhance Glymphatic Clearance as Therapeutic Strategy in Alzheimer's Disease rel 1.00

Alzheimer's Disease starts from the claim that modulating AQP4

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Hypothesis Alpha-theta entrainment therapy to enhance default mode network coherence rel 0.90

Alzheimer's disease through low-frequency oscillatory modulation. Unlike gamma

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Hypothesis Gamma-Entrained PV Interneurons Enable Precision p-tau217-Guided lncRNA Exosome Therapy in Early-Stage Alzheimer's Disease rel 0.90

Alzheimer's Disease starts from the claim that modulating PVALB

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Hypothesis Closed-loop transcranial focused ultrasound with gamma entrainment to restore hippocampal-cortical synchrony via PV interneuron mechanostimulation rel 0.90

Alzheimer's disease. The intervention uses closed-loop tFUS specifically

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Hypothesis Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via SST interneuron disinhibition cascades in Alzheimer's disease rel 0.90

Alzheimer's disease. While amyloid-beta oligomers directly impair PV interneuron

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Hypothesis CYP46A1-Mediated Cholesterol Reduction Prevents eIF2α-Driven Translation Stalling in Neurodegeneration rel 0.80

This hypothesis proposes that CYP46A1 overexpression gene therapy prevents neurodegeneration

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Hypothesis TREM2-Mediated Microglial Metabolic Reprogramming Accelerates Tau Pathological Spread rel 0.80

Alzheimer's disease, suggesting this pathway is critical for circuit

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Hypothesis Excessive C1q/C3/CR3 complement cascade activation initiates pre-symptomatic synaptic loss in Alzheimer's disease rel 0.80

Alzheimer's disease through a well-characterized molecular pathway. The initiation

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Hypothesis CYP46A1 Small Molecule Activator Therapy rel 0.80

Alzheimer's disease through enhanced brain cholesterol metabolism. Small molecule

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Hypothesis TREM2-Mediated Microglial Dysfunction Drives Tau-Induced Blood-Brain Barrier Breakdown rel 0.80

Alzheimer's disease, suggesting this pathway is critical for circuit

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Hypothesis TREM2-Dependent Microglial State Transition as Therapeutic Window in Alzheimer's Disease rel 0.70

Alzheimer's Disease starts from the claim that modulating TREM2

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Hypothesis Regional TREM2-Dependent Lipid Metabolism Determines Cortical Vulnerability in Alzheimer's Disease rel 0.70

Alzheimer's Disease starts from the claim that modulating TREM2

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Hypothesis APOE4 preferentially signals through LRP1 over LDLR, altering endosomal cholesterol trafficking and causing lysosomal cholesterol sequestration that drives lysosomal dysfunction and inflammation rel 0.70

Alzheimer's disease patients, exhibits distinctive receptor binding preferences that

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