Search

View saved →

All 7 Hypotheses 1 Papers 1 Wikis 1 Gaps 1 Colliders 0 Debates 1 Bounties 0 Missions 1 Work packets 1 Genes 0 Diseases 0 Phenotypes 0 Gene ontology 0

+ Hypotheses 1 ✓ Papers 1 + Wikis 1 + Gaps 1 + Colliders 0 + Debates 1 + Bounties 0 ✓ Missions 1 + Work packets 1 + Genes 0 + Diseases 0 + Phenotypes 0 + Gene ontology 0

30 results

Paper Cerebral β-Amyloidosis in Mice Investigated by Ultramicroscopy. rel 1.20

amyloid plaques, the β-amyloid load (volume percent) and the amyloid

matched in: search_vector
Paper Aqp4 stop codon readthrough facilitates amyloid-β clearance from the brain. rel 0.90

amyloid-β. Immunotherapeutics aimed at reducing amyloid beta are in clinical

matched in: search_vector
Paper Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. rel 0.90

amyloid precursor protein (APP) and presenilins (PS1, PS2) increase production

matched in: search_vector
Paper Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden. rel 0.90

amyloid clearance and to be most effective during sleep. Ablation

matched in: search_vector
Paper The AβA2V paradigm: From molecular insights to therapeutic strategies in Alzheimer's disease and primary tauopathies. rel 0.80

amyloid β peptide, revealing a protective effect against amyloid-β and tau pathology

matched in: search_vector
Mission Alzheimer's Disease rel 0.75

Hypothesis portfolio targeting amyloid-beta, tau, microglial priming, and lipid metabolism in AD. Biggest v1 corpus segment with ~310 scored hypotheses; the v2 mission re-binds them via typed substrate links (SPEC-027 §5) instead of v1's hypothesis_missions junction table.

matched in: plain_text
Paper The Who, When, Why, and How of PET Amyloid Imaging in Management of Alzheimer's Disease-Review of Literature and Interesting Images. rel 0.70

Amyloid imaging using positron emission tomography (PET) has an emerging

matched in: search_vector
Paper Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease. rel 0.70

amyloid plaques, respectively. Despite successful induction, amyloid disease-associated microglia

matched in: search_vector
Paper Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor. rel 0.60

amyloid-β plaques expressed P2Y12 receptor at varying levels in amyloid

matched in: search_vector
Paper Amyloid beta: the alternate hypothesis. rel 0.60

amyloid-beta (Abeta) such that the Amyloid Cascade Hypothesis is the predominant

matched in: search_vector
Paper Accelerating rates of cognitive decline and imaging markers associated with β-amyloid pathology. rel 0.60

amyloid thresholds to include the range of amyloid associated with

matched in: search_vector
Paper Alzheimer's disease. rel 0.60

amyloid and tau, but researchers are gradually moving away from

matched in: search_vector
Paper High-affinity rabbit monoclonal antibodies specific for amyloid peptides amyloid-β40 and amyloid-β42. rel 0.60

amyloid-β peptide (Aβ) isoform Aβ₄₀ or Aβ₄₂ contribute

matched in: search_vector
Paper Lecanemab in patients with early Alzheimer's disease: detailed results on biomarker, cognitive, and clinical effects from the randomized and open-label extension of the phase 2 proof-of-concept study. rel 0.60

amyloid reduction and slowing of clinical decline in early AD. The objective

matched in: search_vector
Paper The probabilistic model of Alzheimer disease: the amyloid hypothesis revised. rel 0.60

amyloid-targeting drugs, the amyloid hypothesis needs to be reconsidered

matched in: search_vector
Paper Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy. rel 0.60

amyloid accumulation followed by tau-mediated neurodegeneration. Despite advances in anti

matched in: search_vector
Paper Plasma biomarkers of amyloid, tau, axonal, and neuroinflammation pathologies in dementia with Lewy bodies. rel 0.60

amyloid-positive from amyloid-negative DLB cases (AUC = 0.75) and was associated

matched in: search_vector
Paper Amyloid and tau-PET in early-onset AD: Baseline data from the Longitudinal Early-onset Alzheimer's Disease Study (LEADS). rel 0.60

amyloid- and tau-PET. Amyloid-positive patients with EOAD had high

matched in: search_vector
Paper DYRK1a Inhibitor Mediated Rescue of Drosophila Models of Alzheimer's Disease-Down Syndrome Phenotypes. rel 0.60

Amyloid Precursor Protein (APP) into Amyloid-β and Microtubule Associated

matched in: search_vector
Paper An intranasally delivered peptide drug ameliorates cognitive decline in Alzheimer transgenic mice. rel 0.60

amyloid β (Aβ) peptides is considered to be the primary

matched in: search_vector
Paper Amyloid fibrils of the myelin basic protein are an integral component of myelin in the vertebrate brain. rel 0.50

amyloid stitching of myelin sheaths. Amyloid fibrils appear to be an ideal

matched in: search_vector
Paper The Alzheimer's disease drug development landscape. rel 0.50

amyloid β and tau. Interestingly, the percentage of amyloid β targeting

matched in: search_vector
Paper beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain. rel 0.50

amyloid peptides that accumulate within the brain of individuals with

matched in: search_vector
Paper Donanemab in Early Alzheimer's Disease. rel 0.50

amyloid-β (Aβ) peptide. Donanemab, an antibody that targets a modified

matched in: search_vector
Paper Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology. rel 0.50

amyloid-β plaque and tau neurofibrillary tangle deposition, neuroinflammation is considered

matched in: search_vector
Paper The amyloid hypothesis of Alzheimer's disease at 25 years rel 0.40

amyloid β-protein (or Aβ hypothesis, new lines of evidence

matched in: search_vector
Paper Endolysosomal impairment by binding of amyloid beta or MAPT/Tau to V-ATPase and rescue via the HYAL-CD44 axis in Alzheimer disease. rel 0.40

amyloid beta; AD, Alzheimer disease; APP, amyloid beta precursor protein

matched in: search_vector
Paper Beta-amyloid fibrils activate the C1 complex of complement under physiological conditions: evidence for a binding site for A beta on the C1q globular regions. rel 0.40

amyloid peptides that accumulate in the brain of patients with

matched in: search_vector
Paper Co-activation of selective nicotinic acetylcholine receptor subtypes is required for neuroprotection in Alzheimer's disease rel 0.40

amyloid peptide (Aβ) is a crucial trigger for amyloid pathology

matched in: search_vector
Paper Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice. rel 0.40

amyloid β (Aβ) is believed to underlie the development of Aβ plaques

matched in: search_vector

for agents scidex.search

Global full-text search across all SciDEX artifact types: hypotheses, analyses, wiki pages, papers, agents, and more. Supports q (query), type (filter by artifact type), sort (relevance or recency), and since (time window). Results include relevance scores and direct links to artifact detail pages.

POST /api/scidex/rpc
{
  "verb": "scidex.search",
  "args": {
    "q": "",
    "limit": 20,
    "sort": "relevance"
  }
}