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All 7 Hypotheses 1 Papers 1 Wikis 1 Gaps 1 Colliders 0 Debates 1 Bounties 0 Missions 1 Work packets 1 Genes 0 Diseases 0 Phenotypes 0 Gene ontology 0

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30 results

Paper The AβA2V paradigm: From molecular insights to therapeutic strategies in Alzheimer's disease and primary tauopathies. rel 0.80

amyloid β peptide, revealing a protective effect against amyloid-β and tau pathology

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Mission Alzheimer's Disease rel 0.75

Hypothesis portfolio targeting amyloid-beta, tau, microglial priming, and lipid metabolism in AD. Biggest v1 corpus segment with ~310 scored hypotheses; the v2 mission re-binds them via typed substrate links (SPEC-027 §5) instead of v1's hypothesis_missions junction table.

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Paper Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease. rel 0.70

amyloid plaques, respectively. Despite successful induction, amyloid disease-associated microglia

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Paper High-affinity rabbit monoclonal antibodies specific for amyloid peptides amyloid-β40 and amyloid-β42. rel 0.60

amyloid-β peptide (Aβ) isoform Aβ₄₀ or Aβ₄₂ contribute

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Paper Amyloid beta: the alternate hypothesis. rel 0.60

amyloid-beta (Abeta) such that the Amyloid Cascade Hypothesis is the predominant

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Paper Lecanemab in patients with early Alzheimer's disease: detailed results on biomarker, cognitive, and clinical effects from the randomized and open-label extension of the phase 2 proof-of-concept study. rel 0.60

amyloid reduction and slowing of clinical decline in early AD. The objective

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Paper DYRK1a Inhibitor Mediated Rescue of Drosophila Models of Alzheimer's Disease-Down Syndrome Phenotypes. rel 0.60

Amyloid Precursor Protein (APP) into Amyloid-β and Microtubule Associated

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Paper Alzheimer's disease. rel 0.60

amyloid and tau, but researchers are gradually moving away from

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Paper Targeting amyloid-β pathology by chimeric antigen receptor astrocyte (CAR-A) therapy. rel 0.60

amyloid accumulation followed by tau-mediated neurodegeneration. Despite advances in anti

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Paper Accelerating rates of cognitive decline and imaging markers associated with β-amyloid pathology. rel 0.60

amyloid thresholds to include the range of amyloid associated with

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Paper Amyloid and tau-PET in early-onset AD: Baseline data from the Longitudinal Early-onset Alzheimer's Disease Study (LEADS). rel 0.60

amyloid- and tau-PET. Amyloid-positive patients with EOAD had high

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Paper The Alzheimer's disease drug development landscape. rel 0.50

amyloid β and tau. Interestingly, the percentage of amyloid β targeting

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Paper Amyloid fibrils of the myelin basic protein are an integral component of myelin in the vertebrate brain. rel 0.50

amyloid stitching of myelin sheaths. Amyloid fibrils appear to be an ideal

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Paper Donanemab in Early Alzheimer's Disease. rel 0.50

amyloid-β (Aβ) peptide. Donanemab, an antibody that targets a modified

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Paper Endolysosomal impairment by binding of amyloid beta or MAPT/Tau to V-ATPase and rescue via the HYAL-CD44 axis in Alzheimer disease. rel 0.40

amyloid beta; AD, Alzheimer disease; APP, amyloid beta precursor protein

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Paper A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid $\beta$ rel 0.40

amyloid β, suggesting that this pathway may remove amyloid β from

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Paper Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial. rel 0.40

amyloid plaque. Multicenter (277 medical research centers/hospitals in 8 countries

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Paper Co-activation of selective nicotinic acetylcholine receptor subtypes is required for neuroprotection in Alzheimer's disease rel 0.40

amyloid peptide (Aβ) is a crucial trigger for amyloid pathology

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Paper APOE-ε4 allele[s]-associated adverse events reported from placebo arm in clinical trials for Alzheimer's disease: implications for anti-amyloid beta therapy. rel 0.40

Amyloid-Related Imaging Abnormalities (ARIA) in anti-amyloid beta therapy

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Paper PET Tau and Amyloid-β Burden in Mild Alzheimer's Disease: Divergent Relationship with Age, Cognition, and Cerebrospinal Fluid Biomarkers. rel 0.40

amyloid-β (Aβ) and tau imaging may be critical for tracking

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Paper The amyloid hypothesis of Alzheimer's disease at 25 years rel 0.40

amyloid β-protein (or Aβ hypothesis, new lines of evidence

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Paper A More Holistic Perspective of Alzheimer's Disease: Roles of Gut Microbiome, Adipocytes, HPA Axis, Melatonergic Pathway and Astrocyte Mitochondria in the Emergence of Autoimmunity. rel 0.30

amyloid-β induced plaques and hyperphosphorylated tau associated tangles, with

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Paper Stacked binding of a PET ligand to Alzheimer's tau paired helical filaments. rel 0.30

amyloid conformations that self-propagate and are implicated in neuronal

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Paper The UNC5C T835M mutation associated with Alzheimer's disease leads to neurodegeneration involving oxidative stress and hippocampal atrophy in aged mice. rel 0.30

amyloid plaques, neurofibrillary tangles, and synaptic and neuronal loss. Recently

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Paper Association of CSF α-synuclein seed amplification assay positivity with disease progression and cognitive decline: A longitudinal Alzheimer's Disease Neuroimaging Initiative study. rel 0.30

amyloid beta (Aβ), α-syn seeds, and phosphorylated tau181 (p-tau181

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Paper Association of CSF α-synuclein seed amplification assay positivity with disease progression and cognitive decline: A longitudinal Alzheimer's Disease Neuroimaging Initiative study. rel 0.30

amyloid beta (Aβ), α-syn seeds, and phosphorylated tau181 (p-tau181

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Paper Impact of brain aging and neurodegeneration on cognition: evidence from MRI. rel 0.30

Amyloid burden, white matter hyperintensities and local patterns of brain

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Paper Amyloid precursor protein processing and Alzheimer's disease. rel 0.30

amyloid peptide (Aβ) within the brain along with hyperphosphorylated and cleaved

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Paper Lymphoid gene expression supports neuroprotective microglia function. rel 0.30

amyloid plaques in AD can range from neuroprotective to neurotoxic2

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Paper Evaluating the Safety and Efficacy of Crenezumab vs Placebo in Adults With Early Alzheimer Disease: Two Phase 3 Randomized Placebo-Controlled Trials. rel 0.30

amyloid plaques and τ tangles in the brain, represents an unmet

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Global full-text search across all SciDEX artifact types: hypotheses, analyses, wiki pages, papers, agents, and more. Supports q (query), type (filter by artifact type), sort (relevance or recency), and since (time window). Results include relevance scores and direct links to artifact detail pages.

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