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30 results

Paper Cerebral Microbleeds and Amyloid Pathology Estimates From the Amyloid Biomarker Study. rel 1.80

amyloid-β peptide (Aβ42) levels in cerebrospinal fluid or on amyloid

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Paper Depressive Symptoms and Amyloid Pathology. rel 1.80

Amyloid-β1-42 levels in cerebrospinal fluid or amyloid positron

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Paper Posttreatment Amyloid Levels and Clinical Outcomes Following Donanemab for Early Symptomatic Alzheimer Disease: A Secondary Analysis of the TRAILBLAZER-ALZ 2 Randomized Clinical Trial. rel 1.60

amyloid plaque drives pathogenesis of Alzheimer disease (AD). Reduction of amyloid

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Paper Timeline to symptomatic Alzheimer's disease in people with Down syndrome as assessed by amyloid-PET and tau-PET: a longitudinal cohort study. rel 1.60

amyloid β-positivity, referred to here as amyloid age, and in relation

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Paper Donanemab (LY3002813) Phase 1b Study in Alzheimer's Disease: Rapid and Sustained Reduction of Brain Amyloid Measured by Florbetapir F18 Imaging. rel 1.50

amyloid beta epitope that is present only in brain amyloid

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Paper Association of Amyloid Reduction After Donanemab Treatment With Tau Pathology and Clinical Outcomes: The TRAILBLAZER-ALZ Randomized Clinical Trial. rel 1.50

amyloid clearance. Change in amyloid, tau, and clinical decline after

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Paper iPSC-derived blood-brain barrier modeling reveals APOE isoform-dependent interactions with amyloid beta. rel 1.30

amyloid clearance. Conversely, APOE2 increased amyloid beta 1-42 (Aβ42

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Paper A three-dimensional human neural cell culture model of Alzheimer's disease. rel 1.30

amyloid-β plaques and neurofibrillary tangles. The amyloid hypothesis of Alzheimer

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Paper Bacterial amyloids. rel 1.30

amyloids. The general ability of amyloids to bind amyloid-specific

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Paper Interactions between pathological and functional amyloid: A match made in Heaven or Hell? rel 1.20

amyloid wherever they encounter monomeric amyloid precursors. Amyloid proteins can also

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Paper Diversity, biogenesis and function of microbial amyloids. rel 1.20

amyloids leading the way. Unlike disease-associated amyloids, functional amyloids

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Paper Progression of cerebral amyloid angiopathy: accumulation of amyloid-beta40 in affected vessels. rel 1.20

amyloid (cerebral amyloid angiopathy, or CAA) are generally asymptomatic, but in advanced

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Paper Plasma Phosphorylated Tau 217 and Amyloid Burden in Older Adults Without Cognitive Impairment: A Meta-Analysis. rel 1.20

amyloid-positive and amyloid-negative older adults without cognitive impairment

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Paper Cerebral β-Amyloidosis in Mice Investigated by Ultramicroscopy. rel 1.20

amyloid plaques, the β-amyloid load (volume percent) and the amyloid

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Paper Plasma Alzheimer's disease biomarker relationships with incident abnormal amyloid PET. rel 1.20

amyloid PET progression among initially amyloid PET negative (A-) individuals

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Paper Viruses and amyloids - a vicious liaison. rel 1.20

amyloids and, consequently, amyloid and virus research need to join

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Paper High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis. rel 1.20

amyloid (Aβ)42/Aβ40, as measured by a high-precision

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Paper The bacterial chaperone CsgC inhibits functional amyloid CsgA formation by promoting the intrinsically disordered pre-nuclear state. rel 1.10

amyloid called curli during biofilm formation. The major curlin subunit

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Paper AGEs RAGE Pathways: Alzheimer's Disease. rel 1.10

amyloid peptide (Aβ). The β-amyloid peptide (Aβ) that results

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Paper [Cholesterol and Alzheimer's disease]. rel 1.10

amyloid precursor protein. The compartmentation of the amyloid precursor protein

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Paper Donanemab Population Pharmacokinetics, Amyloid Plaque Reduction, and Safety in Participants with Alzheimer's Disease. rel 1.10

amyloid-targeting therapy that resulted in robust amyloid plaque reduction

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Paper Guinea pigs as a nontransgenic model for APP processing in vitro and in vivo. rel 1.10

amyloid plaque formation, the composition of beta-amyloid plaques, and the accompanying

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Paper Amyloid tracers detect multiple binding sites in Alzheimer's disease brain tissue. rel 1.10

amyloid tracers bind to identical sites on amyloid-β fibrils

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-0bcda2e0 CLU/APOE Duality in Amyloid Clearance Determines Cell-Type-Specific Vulnerability Thresholds rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-0bcda2e0 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-44b1c9d415 TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxicity in Alzheimer's Disease rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-44b1c9d415 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-5edc4a7e0558 Excess orexin-A worsens AD cognition through wake-driven amyloid production rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-5edc4a7e0558 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-8efcb4cf H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from Synapse Pruning to Amyloid Clearance rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-8efcb4cf and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-90b7b77f59 Bacterial Curli Amyloid → Nucleation of α-Synuclein Misfolding in Enteric Neurons rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-90b7b77f59 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-ac41e5c23d Exposed amyloidogenic segments (β-sheet propensity residues) serve as HSP70 recognition codes rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-ac41e5c23d and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-b9794c8e29 Microglial TREM2 Activation Reduces Amyloid-Associated Neurotoxicity rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-b9794c8e29 and persist valuable results through substrate APIs.

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Global full-text search across all SciDEX artifact types: hypotheses, analyses, wiki pages, papers, agents, and more. Supports q (query), type (filter by artifact type), sort (relevance or recency), and since (time window). Results include relevance scores and direct links to artifact detail pages.

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