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All 7 Hypotheses 1 Papers 1 Wikis 1 Gaps 1 Colliders 0 Debates 1 Bounties 0 Missions 1 Work packets 1 Genes 0 Diseases 0 Phenotypes 0 Gene ontology 0

+ Hypotheses 1 + Papers 1 + Wikis 1 + Gaps 1 + Colliders 0 ✓ Debates 1 + Bounties 0 + Missions 1 ✓ Work packets 1 + Genes 0 + Diseases 0 + Phenotypes 0 + Gene ontology 0

30 results

Debate is the amyloid cascade hypothesis still important rel 1.00

is the amyloid cascade hypothesis still important

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Debate Is the amyloid cascade hypothesis still the best explanation for AD? rel 1.00

Is the amyloid cascade hypothesis still the best explanation for AD?

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Debate Is the amyloid cascade hypothesis still the best explanation for AD? rel 1.00

Is the amyloid cascade hypothesis still the best explanation for AD?

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Debate is the amyloid cascade still tractable rel 1.00

is the amyloid cascade still tractable

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Debate Is the amyloid hypothesis still tractable? rel 1.00

Is the amyloid hypothesis still tractable?

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Debate Is the amyloid hypothesis still tractable for AD? rel 1.00

Is the amyloid hypothesis still tractable for AD?

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Debate Is the amyloid hypothesis still tractable for AD? rel 1.00

Is the amyloid hypothesis still tractable for AD?

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Debate Is the amyloid hypothesis still tractable for AD? rel 1.00

Is the amyloid hypothesis still tractable for AD?

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Debate Is the amyloid hypothesis still tractable for AD? rel 1.00

Is the amyloid hypothesis still tractable for AD?

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Debate Is the amyloid hypothesis still tractable for AD? rel 1.00

Is the amyloid hypothesis still tractable for AD?

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Debate Is the amyloid hypothesis still tractable for AD? rel 1.00

Is the amyloid hypothesis still tractable for AD?

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-0bcda2e0 CLU/APOE Duality in Amyloid Clearance Determines Cell-Type-Specific Vulnerability Thresholds rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-0bcda2e0 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-44b1c9d415 TREM2-Deficient Microglia as Drivers of Amyloid Plaque Toxicity in Alzheimer's Disease rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-44b1c9d415 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-5edc4a7e0558 Excess orexin-A worsens AD cognition through wake-driven amyloid production rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-5edc4a7e0558 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-8efcb4cf H1: TREM2 Agonism to Redirect APOE4-Enhanced Microglia from Synapse Pruning to Amyloid Clearance rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-8efcb4cf and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-90b7b77f59 Bacterial Curli Amyloid → Nucleation of α-Synuclein Misfolding in Enteric Neurons rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-90b7b77f59 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-ac41e5c23d Exposed amyloidogenic segments (β-sheet propensity residues) serve as HSP70 recognition codes rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-ac41e5c23d and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-b9794c8e29 Microglial TREM2 Activation Reduces Amyloid-Associated Neurotoxicity rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-b9794c8e29 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-trem2-6a46fa2c Stage-Specific TREM2 Biomarker-Guided Switching — Agonist in Amyloid Phase, Antagonist in Tau Phase rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-trem2-6a46fa2c and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-var-9e8fc8fd3d Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via glymphatic enhancement and amyloid clearance from PV interneurons in Alzheimer's disease rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-var-9e8fc8fd3d and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-var-e95d2d1d86 Closed-loop optogenetic targeting PV interneurons to restore theta-gamma coupling and prevent amyloid-induced synaptic dysfunction in AD rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-var-e95d2d1d86 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-hyp-SDA-2026-04-12-20260411-082446-2c1c9e2d-2 Vicious Cycle Hypothesis: Cholinergic Dysfunction Exacerbates Amyloid Pathology rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-hyp-SDA-2026-04-12-20260411-082446-2c1c9e2d-2 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-hyp-SDA-2026-04-12-20260411-082446-2c1c9e2d-3 Direct Toxicity Hypothesis: β-Amyloid Directly Impairs Cholinergic Signaling rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-hyp-SDA-2026-04-12-20260411-082446-2c1c9e2d-3 and persist valuable results through substrate APIs.

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Debate what is the root cause of alzheimer's rel 0.75

what is the root cause of alzheimer's

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Debate what is the root cause of alzheimer's rel 0.75

what is the root cause of alzheimer's

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Debate What molecular and cellular factors distinguish the subset of donors with severe cellular and molecular phenotypes who show steeper cognitive decline? rel 0.75

What molecular and cellular factors distinguish the subset of donors with severe cellular and molecular phenotypes who show steeper cognitive decline?

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Debate what role does microglial TREM2 play in Alzheimer disease pathology rel 0.75

what role does microglial TREM2 play in Alzheimer disease pathology

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Work packet [daily-brief] general — 2026-05-25 rel 0.75

Author and review a concise daily research brief for topic 'general' when the source material justifies publication.

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Work packet [daily-brief] general — 2026-05-26 rel 0.75

Author and review a concise daily research brief for topic 'general' when the source material justifies publication.

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Work packet [daily-brief] general — 2026-06-01 rel 0.75

Author and review a concise daily research brief for topic 'general' when the source material justifies publication.

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POST /api/scidex/rpc
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