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✓ Hypotheses 1 ✓ Papers 1 + Wikis 1 + Gaps 0 + Colliders 0 + Debates 1 + Bounties 0 + Missions 1 + Work packets 1 + Genes 0 + Diseases 0 + Phenotypes 0 + Gene ontology 0

30 results

Hypothesis LRP1-Autophagy BBB Permeabilization for Antibody Transport rel 3.90

autophagy pathway in BMECs. [PMID:31504123]. 2. Pharmacological autophagy induction

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Hypothesis H2: Impaired Autophagy Receptor Recruitment Traps G3BP1 Granules rel 2.10

autophagy. TBK1 phosphorylates key autophagy receptors including p62/SQSTM1 (sequestosome 1) at Ser403

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Hypothesis C9orf72 DPRs Impair Autophagy Receptor Docking on Stress Granules rel 1.70

autophagy receptor function through steric occlusion of critical ubiquitin-binding

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Hypothesis H7: mTOR Hyperactivity Blocks Autophagy, Permitting Tau Seeding rel 1.60

autophagy in response to metabolic demands. In cortical layer II neurons

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Hypothesis Autophagic Flux Enhancement Synergizes With Chaperones to Clear High-Molecular-Weight Tau Seeds rel 1.50

autophagy receptor that bridges ubiquitinated protein aggregates to the autophagy

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Hypothesis Autophagosome-Lysosome Fusion Defects as Primary Driver of α-Synuclein Propagation rel 1.40

autophagy through precise membrane fusion events. VPS41 functions as a key component

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Hypothesis Chaperone-Autophagy Coupling Prevents Aggregate Persistence by Directing Seeds to Selective Autophagy rel 1.30

autophagy pathways, particularly chaperone-mediated autophagy (CMA) and aggrephagy. The mechanism

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Hypothesis Autophagy-Epigenetic Feedback Loop Creates a Compounding Biomarker Signal — Autophagy Flux Methylation as an AD Stage Chronometer rel 1.30

autophagy regulatory genes, which further suppresses autophagy in a self

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Paper ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms. rel 1.30

autophagy, ROS-HIF1-BNIP3/NIX-autophagy, and ROS-TIGAR-autophagy. Autophagy

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Hypothesis ALS-Linked OPTN/TBK1 Mutations Impair Phosphorylation Cascade Required for Pathological SG Recognition rel 1.20

autophagy axis. TBK1 (TANK-binding kinase 1) functions as a central

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Hypothesis FUS Mutations Alter Stress Granule Material Properties to Confer Autophagy Resistance rel 1.20

autophagy-mediated clearance through multiple mechanisms. The autophagy machinery, including

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Hypothesis ALS-Associated G3BP1/2 Mutations Disrupt TRIM21 Binding Interfaces rel 1.10

autophagy flux is reflected in CSF levels of autophagy-related

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Paper Autophagy and cancer drug resistance in dialogue: Pre-clinical and clinical evidence. rel 1.00

autophagy has a complex physio-pathological role. In some circumstances

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Paper Regulation of Mammalian Autophagy in Physiology and Pathophysiology rel 1.00

autophagy is a bulk degradation process that mediates the clearance

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Paper Guidelines for the use and interpretation of assays for monitoring autophagy. rel 1.00

autophagy. Since then, research on this topic has continued to accelerate

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Paper Autophagy drives fibroblast senescence through MTORC2 regulation. rel 1.00

autophagy related 4A cysteine peptidase; ATG7: autophagy gene 7; C12FDG

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Paper Autophagy-dependent cell death. rel 1.00

autophagy. Although autophagy often accompanies cell death following many toxic

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Paper Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective. rel 0.90

autophagy in the pathogenesis of PCOS. Defective autophagy in the follicular

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Paper Autophagy in ovary and polycystic ovary syndrome: role, dispute and future perspective. rel 0.90

autophagy in the pathogenesis of PCOS. Defective autophagy in the follicular

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Paper Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity. rel 0.90

autophagy markers WIPI2, RB1CC1/FIP200 and ATG16L1 indicates increased initiation of autophagy

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Paper SIRT1 Positively Regulates Autophagy and Mitochondria Function in Embryonic Stem Cells Under Oxidative Stress rel 0.90

autophagy. This suggests a role for SIRT1 in regulating autophagy

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Paper The interplay of ROS and the PI3K/Akt pathway in autophagy regulation. rel 0.90

autophagy, while its β catalytic subunit promotes autophagy in response

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Paper Alpha-Synuclein defects autophagy by impairing SNAP29-mediated autophagosome-lysosome fusion. rel 0.90

autophagy. Here, we used a combination of molecular biology and immunochemistry

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Paper Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase. rel 0.90

Autophagy mediates the cellular response to nutrient deprivation, protein aggregation

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Paper The interplay of ROS and the PI3K/Akt pathway in autophagy regulation. rel 0.90

autophagy, while its β catalytic subunit promotes autophagy in response

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Hypothesis Lysosomal Clearance Capacity Determines Therapeutic Window—Autophagy Enhancement Required Before Critical Accumulation rel 0.80

autophagy-lysosomal degradation of pathological protein aggregates, specifically targeting the mTORC1/ULK1

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Hypothesis Pharmacological EZH2 Inhibition Resets Polycomb-Mediated Repression of Synaptic Transmission Genes in 3xTg-AD Neurons rel 0.80

autophagy regulators. Specifically, EZH2 hyperactivity results in aberrant silencing of synaptic

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Hypothesis Chaperone-Autophagy Coupling Prevents Aggregate Persistence by Shunting Seeds to Selective Autophagy rel 0.80

autophagy coupling hypothesis centers on the critical interaction between p62/SQSTM1

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Hypothesis CHIP-mediated K63-linked ubiquitination redirects oligomeric pathologic conformers to selective autophagy through p62/SQSTM1 rel 0.80

autophagy pathways rather than proteasomal degradation for clearance of large

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Paper TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation. rel 0.80

autophagy. Inhibition of MTORC1 by rapamycin induced autophagy and increased

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