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30 results

Paper Genetic Insights into the Impact of Complement in Alzheimer's Disease. rel 1.30

complement in disease aetiology. Genetic variations in complement genes are widespread

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Paper Innate immunity and brain inflammation: the key role of complement. rel 1.10

Complement fragments (opsonins; C1q, C3b and iC3b) interact with complement

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Paper The Importance of Complement-Mediated Immune Signaling in Alzheimer's Disease Pathogenesis. rel 1.00

complement system is responsible for our defense against pathogens. The complement

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Paper Complement System and the Kidney: Its Role in Renal Diseases, Kidney Transplantation and Renal Cell Carcinoma. rel 0.90

complement system, immune cells, and mediators of inflammation provides an efficient

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Paper The complement system and human autoimmune diseases. rel 0.70

complement activation pathway (especially C1q, r, s, and C4) are the strongest

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Paper Synaptic pruning genes networks in Alzheimer's disease: correlations with neuropathology and cognitive decline. rel 0.60

complement system components (C1QA, C1QB, C1QC, C1S, C1R, C3), microglial

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Paper The classical complement cascade mediates CNS synapse elimination. rel 0.60

complement protein C1q or the downstream complement protein C3 exhibit

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Paper A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica. rel 0.50

complement activation, in producing the necrotizing demyelination seen in the spinal

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Paper HIV Tat causes synapse loss in a mouse model of HIV-associated neurocognitive disorder that is independent of the classical complement cascade component C1q. rel 0.50

complement deposition on synapses followed by microglial engulfment has been

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Paper Free radicals upregulate complement expression in rabbit isolated heart. rel 0.40

complement activation can injure tissue. Our study determined whether free

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Paper Functional evaluation of factor H genetic and acquired abnormalities: application for atypical hemolytic uremic syndrome (aHUS). rel 0.40

complement pathway secondary to a not well-understood trigger event

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Paper Dual roles of complement in cerebral amyloid angiopathy: A two-compartment framework across the blood-brain barrier. rel 0.40

Complement is increasingly recognized as a context-dependent contributor to cerebral

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Paper 10.1038/nature18283 rel 0.40

complement cascade, a key component of innate immune pathogen defence

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Paper The pathology of central nervous system inflammatory demyelinating disease accompanying myelin oligodendrocyte glycoprotein autoantibody. rel 0.30

Complement deposition is present in all active white matter lesions

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Paper Pioglitazone attenuates complement-mediated microglial synaptic engulfment in an Alzheimer's disease model. rel 0.30

complement-mediated microglial synaptic engulfment and attenuating synapse loss. These

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Paper Nonclinical Development of ANX005: A Humanized Anti-C1q Antibody for Treatment of Autoimmune and Neurodegenerative Diseases. rel 0.30

complement cascade. The safety and tolerability of ANX005 are currently

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Paper ApoE attenuates unresolvable inflammation by complex formation with activated C1q. rel 0.30

complement cascade (CCC), resulting in leukocyte infiltration of the choroid

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Paper Complement C1qB and C4 mRNAs responses to lesioning in rat brain. rel 0.30

complement components (C) in the adult rat brain and describe

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Paper Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice. rel 0.30

Complement-mediated synaptic pruning is essential in the developing and healthy

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Paper Complement activation by ligand-driven juxtaposition of discrete pattern recognition complexes. rel 0.30

complement, the pattern recognition molecules (PRMs) mannan-binding lectin (MBL) and ficolins

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Paper Oral Iptacopan Monotherapy in Paroxysmal Nocturnal Hemoglobinuria. rel 0.30

complement inhibitors. Iptacopan, a first-in-class oral factor B inhibitor

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Paper Genome-wide consensus transcriptional signatures identify synaptic pruning linking Alzheimer's disease and epilepsy. rel 0.30

complement components. Gene regulatory network analysis identified TYROBP as the key regulatory

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Paper Neuroprotective mechanisms of cobalamin in ischemic stroke insights from network pharmacology and molecular simulations. rel 0.20

complement binding, and lipoprotein particle binding. KEGG analysis identified complement

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Paper Complement activation and the resulting placental vascular insufficiency drives fetal growth restriction associated with placental malaria. rel 0.20

Complement C5a and C5a receptor levels are increased with PM. C5a is implicated

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Paper Aquaporin-4: orthogonal array assembly, CNS functions, and role in neuromyelitis optica. rel 0.20

complement by intracerebral injection develop characteristic NMO lesions with neuroinflammation

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Paper Development of Proteomic Prediction Models for Transition to Psychotic Disorder in the Clinical High-Risk State and Psychotic Experiences in Adolescence. rel 0.20

complement and coagulation cascade. A model based on the 10 most

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Paper Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau. rel 0.20

complement subnetwork identified by multi-scale gene network studies of postmortem

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Paper Microglia in Alzheimer's Disease: An Unprecedented Opportunity as Prospective Drug Target. rel 0.20

complement factors, toll-like receptors, and genetic variants result in Aβ' phagocytosis

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Paper Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia. rel 0.20

complement factor H (CFH) gene was strongly associated with serum

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Paper Nuclear organisation of some immunohistochemically identifiable neural systems in five species of insectivore-Crocidura cyanea, Crocidura olivieri, Sylvisorex ollula, Paraechinus aethiopicus and Atelerix frontalis. rel 0.20

complement of these neural systems in comparison to those of other

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