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✓ Hypotheses 1 + Papers 1 + Wikis 1 ✓ Gaps 1 + Colliders 0 + Debates 1 + Bounties 0 + Missions 0 + Work packets 1 + Genes 0 + Diseases 0 + Phenotypes 0 ✓ Gene ontology 0

30 results

Hypothesis SASP-Mediated Complement Cascade Amplification rel 8.10

complement—they create localized "complement storms" with concentrations 100-1000x higher

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Hypothesis Complement-Mediated Synaptic Pruning Dysregulation rel 7.60

complement regulatory proteins. This binding initiates the classical complement cascade

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Hypothesis Complement Cascade Activation Bridges Microglial OxPC Sensing to Synaptic Vulnerability rel 6.70

complement cascade)` and the pathway label is `Classical complement cascade

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Hypothesis Complement C1q Suppression as Mechanism Linking Exercise Plasma to PV Interneuron Protection rel 6.20

complement inhibitors target C5 or C3. Identifier COMPLEMENT_LANDSCAPE. 3. C1q has non-complement

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Hypothesis Complement C1QA Spatial Gradient in Cortical Layers rel 5.70

complement functions in deeper cortical layers (where complement aids debris

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Hypothesis Complement Cascade Inhibition Synaptic Protection rel 4.90

Complement Cascade Inhibition Synaptic Protection Mechanism of Action The complement

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Hypothesis Complement-SASP Amplification Cascade as Mechanistic Link rel 4.80

complement-SASP amplification cascade represents a mechanistic nexus where cellular

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Hypothesis Synaptic Pruning Precision Therapy rel 4.70

complement receptors (CR1/CR3) recognize complement-tagged synapses and engulf them

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Hypothesis Complement C1QA Inhibition Synergizes with PV Interneuron Modulation rel 4.70

Complement C1QA and Synaptic Pruning in Neurodegeneration The complement cascade

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Hypothesis Targeting SASP-Complement Amplification Through HIF-1α Downstream Effectors rel 4.60

Complement Component 3):** - C3 is the central complement protein activated

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Hypothesis Complement-Mediated Synaptic Protection rel 4.40

Complement-Mediated Synaptic Protection ### Mechanistic Hypothesis Overview The "Complement-Mediated

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Hypothesis Complement C1q Subtype Switching rel 4.20

Complement functional assays (CH50, AH50) ensure residual complement activity remains

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Hypothesis CREB-Dependent Differential Complement Regulator Positioning for Activity-Based Synaptic Vulnerability Control rel 4.00

complement vulnerability. This activity-dependent complement regulator positioning enables precise

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Hypothesis Activity-Dependent CD55/CD46 Trafficking and Synaptic Surface Localization rel 4.00

complement regulators CD55 and CD46 to synaptic surfaces represents a dynamic

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Hypothesis Differential Complement Regulator Expression on Synaptic Membranes (CD55/CD46) rel 4.00

complement regulation. Biomarker-guided patient selection utilizes CSF complement profiles

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Hypothesis Microglial TREM2-Complement Axis Modulation rel 3.90

complement axis represents a fundamental regulatory network controlling neuroinflammation and synaptic

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Hypothesis Complement C1q Mimetic Decoy Therapy rel 3.80

Complement Component 1q Subcomponent A):** - First component of classical complement

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Hypothesis Microglial Priming via NF-κB-Dependent DAM Phenotype and Complement Biosynthesis rel 3.70

complement tagging creates a molecular bridge between complement-opsonized synapses

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Hypothesis C1q Inhibition Prevents Synaptic Mitochondrial Dysfunction via Microglial-Neuronal Cross-Talk Normalization rel 3.40

complement modulation, particularly given that complement activation may precede overt

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Hypothesis Excessive C1q/C3/CR3 complement cascade activation initiates pre-symptomatic synaptic loss in Alzheimer's disease rel 3.10

complement-intact 5xFAD controls. Pharmacological complement inhibition using CVF (cobra

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Hypothesis C1QA/C1QB Subunit-Specific Inhibition to Block Aberrant PV Interneuron Input Elimination in Alzheimer's Disease rel 2.80

complement activation. In Alzheimer's disease pathophysiology, aberrant complement activation

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Hypothesis Direct C1q Binding Enables FcγR-Independent Complement Activation on Tumor Cells rel 2.70

complement activation, and novel complement-activating therapeutics show promise in EGFR

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Hypothesis TREM2-C1Q Competitive Binding to Prevent Complement-Mediated Cholinergic Synapse Loss rel 2.60

complement tagging recruits complement receptor 3 (CR3/CD11b-CD18) on microglia, facilitating

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Hypothesis Astrocyte-Selective APOE4 Silencing via Lipid Nanoparticles rel 2.60

complement component C1q and triggering receptor expressed on myeloid cells

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Hypothesis Senescent Cell ASM-Complement Cascade Intervention rel 2.50

Complement Cascade Intervention starts from the claim that modulating SMPD1

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Hypothesis TNF-α–C1r/C1s Bridge Between NF-κB and Classical Complement Cascade rel 2.50

complement cascade activation in sevoflurane-induced neurotoxicity. At the molecular

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Hypothesis TNF-α/IL-1β-Cx43 Hemichannel Axis as Upstream Link Between SASP and Synaptic Pruning rel 2.40

complement-producing state. Activated microglia upregulate synthesis of complement component

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Hypothesis TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimination Through Type I IFN Hyperactivation rel 2.20

complement-driven synaptic pruning. TBK1 (TANK-binding kinase 1) serves

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Hypothesis NFκB/C1Q SASP Modulation for Synaptic Protection rel 2.10

complement amplification loop that drives synaptic loss in Alzheimer's disease

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Hypothesis LPS-primed microglial trained immunity establishes persistent H3K4me3 landscapes at complement gene loci, driving hyperactive synaptic pruning in late-life neurodegeneration rel 2.10

complement cascade genes including C1QA, C1QB, C1QC, C3, and complement

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