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30 results

Paper Thrombospondin-1 inhibits alternative complement pathway activation in antineutrophil cytoplasmic antibody-associated vasculitis. rel 1.30

complement pathway. TSP-1 binds to complement proteins and inhibits

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Paper Alzheimer's disease-associated complement gene variants influence plasma complement protein levels. rel 1.30

complement regulators clusterin (CLU) and complement receptor 1 (CR1), recognised

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Paper Genetic Insights into the Impact of Complement in Alzheimer's Disease. rel 1.30

complement in disease aetiology. Genetic variations in complement genes are widespread

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Paper Longitudinal investigation of the T helper (Th)1-Th2 balance and complement system in clinical high risk for psychosis cohort. rel 1.10

complement system influences this imbalance during psychosis onset. This study

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Paper Divergent complement system activation in two clinically distinct murine models of multiple sclerosis. rel 1.10

complement system, specifically the classical complement pathway, was associated with

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Paper Innate immunity and brain inflammation: the key role of complement. rel 1.10

Complement fragments (opsonins; C1q, C3b and iC3b) interact with complement

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Paper Messengers of coagulopathy: complement-carrying extracellular vesicles in SARS-CoV-2 infection. rel 1.10

complement-active phenotype. Sub-lytic complement attack, particularly membrane attack

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Paper The complement system as a target in cancer immunotherapy. rel 1.00

complement components, is pivotal. The complement system, known for its role

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Paper Complement factor B inhibitor LNP023 improves lupus nephritis in MRL/lpr mice. rel 1.00

complement factors in the alternative complement pathway were analyzed in the 3 groups

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Paper The Importance of Complement-Mediated Immune Signaling in Alzheimer's Disease Pathogenesis. rel 1.00

complement system is responsible for our defense against pathogens. The complement

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Paper Complement is activated in progressive multiple sclerosis cortical grey matter lesions. rel 1.00

complement pathway protein C1q and the alternative complement pathway activation

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Paper The complement cascade in Alzheimer's disease: modern implications of an ancient immune protagonist. rel 1.00

complement activation and review the therapeutic potential of targeting complement

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-01685bc3b9 Differential Complement Regulator Expression on Synaptic Membranes (CD55/CD46) rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-01685bc3b9 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-16591043d1 Selective blockade of classical-pathway activation downstream of C1q will reduce synaptotoxic complement amplification while preserving beneficial C1q recognition functions rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-16591043d1 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-3616325a Microglial TREM2-Complement Axis Modulation rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-3616325a and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-a5bc82c685 Excessive C1q/C3/CR3 complement cascade activation initiates pre-symptomatic synaptic loss in Alzheimer's disease rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-a5bc82c685 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-a8165b3b Complement-Mediated Synaptic Pruning Dysregulation rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-a8165b3b and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-a9f2570b Targeting SASP-Complement Amplification Through HIF-1α Downstream Effectors rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-a9f2570b and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-af0ec8d843 Complement C1q-Mediated Synaptic Pruning Drives Early Cognitive Decline in Alzheimer's Disease rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-af0ec8d843 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-e64a33a8 Complement Cascade Inhibition Synaptic Protection rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-e64a33a8 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-f4a63646 Complement-SASP Amplification Cascade as Mechanistic Link rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-f4a63646 and persist valuable results through substrate APIs.

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Paper NLRP3 is Required for Complement-Mediated Caspase-1 and IL-1beta Activation in ICH. rel 0.90

complement function. As a result, complement 3a (C3a) and complement

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Paper Complement System and the Kidney: Its Role in Renal Diseases, Kidney Transplantation and Renal Cell Carcinoma. rel 0.90

complement system, immune cells, and mediators of inflammation provides an efficient

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Paper Complement, Inflammasome, and Microglial Crosstalk in Glaucoma: From Neurodegeneration to Immune-Based Precision Therapy. rel 0.80

Complement, Inflammasome, and Microglial Crosstalk in Glaucoma: From Neurodegeneration to Immune

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Paper Pentraxin 3 recruits complement factor H to protect against oxidative stress-induced complement and inflammasome overactivation. rel 0.80

complement by interacting with complement components. Here, we show that

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Paper The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration. rel 0.80

Complement overactivation mediates microglial synapse elimination in neurological diseases such

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Paper Association of age-related macular degeneration with complement activation products, smoking, and single nucleotide polymorphisms in South Carolinians of European and African descent. rel 0.80

complement factor H (CFH) activity, and the complement activation products

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Paper Dual role of complement in neuronal repair. rel 0.80

complement system, long regarded as an arm of innate immunity

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Work packet [agent-work] @ylek-avaglintri: produce_numeric_science_gate rel 0.75

Convert Kyle's SEA-AD × ROSMAP × Mathys 2023 microglia-OPC reconciliation plan into one low-cost numeric gate: test whether early inflammatory microglia abundance is positively coupled to OPC remyelination-state signal across AD pseudoprogression strata, or publish the exact missing donor/cell-count blocker.

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Paper Protective immune responses against West Nile virus are primed by distinct complement activation pathways. rel 0.70

complement plays a critical role in controlling WNV infection in complement

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