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All 6 Hypotheses 1 Papers 1 Wikis 1 Gaps 1 Colliders 0 Debates 1 Bounties 0 Missions 0 Work packets 1 Genes 0 Diseases 0 Phenotypes 0 Gene ontology 0

✓ Hypotheses 1 + Papers 1 ✓ Wikis 1 + Gaps 1 ✓ Colliders 0 + Debates 1 + Bounties 0 + Missions 0 + Work packets 1 + Genes 0 + Diseases 0 ✓ Phenotypes 0 + Gene ontology 0

30 results

Wiki Complement System in Neurodegeneration rel 18.30

complement system. TDP-43 can activate complement, and complement proteins

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Wiki Complement Activation in Corticobasal Degeneration rel 16.90

complement production - TREM2 variants affect complement-mediated phagocytosis - Microglial complement

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Wiki Complement-Mediated Synapse Loss rel 14.80

Complement-DAM Interaction | DAM Marker | Complement Relationship | |------------|------------------------| | TREM2 | Triggers complement

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Wiki Complement System rel 13.60

Complement Cascade Overview The complement system operates through three activation

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Wiki C1R — Complement Component 1, R Subcomponent rel 10.70

Complement-mediated inflammation - **Therapeutic potential** — Complement inhibition ## Therapeutic Implications ### Complement

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Wiki Complement System Pathway in Neurodegeneration rel 10.30

Complement Pathway in Neurodegeneration ## Overview The complement system is a critical

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Wiki Complement Dysregulation in CBS and 4R Tauopathies rel 10.10

complement activation. ### Regional Patterns of Complement Activation Complement activation in CBS follows

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Wiki Complement Component 3 (C3) rel 9.70

COMPLEMENT["COMPLEMENT"] -->|"associated with"| Complement["Complement"] COMPLEMENT["COMPLEMENT"] -->|"regulates"| Complement

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Wiki Validated Hypothesis: SASP-Mediated Complement Cascade Amplification rel 9.60

complement—they create localized "complement storms" with concentrations 100-1000x higher

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Wiki Complement System in Neurodegeneration rel 8.20

complement-mediated clearance - [Ferroptosis](/entities/ferroptosis) — complement-CR3-ferroptosis axis - [Complement

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Hypothesis SASP-Mediated Complement Cascade Amplification rel 8.10

complement—they create localized "complement storms" with concentrations 100-1000x higher

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Wiki complement-c1q-inhibitor-therapy rel 7.90

COMPLEMENT["COMPLEMENT"] -->|"associated with"| Complement["Complement"] COMPLEMENT["COMPLEMENT"] -->|"regulates"| Complement

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Wiki C3 Protein (Complement Component 3) rel 7.70

complement activation --- ## Molecular Mechanisms ### Complement Activation in the Brain The complement

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Hypothesis Complement-Mediated Synaptic Pruning Dysregulation rel 7.60

complement regulatory proteins. This binding initiates the classical complement cascade

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Wiki Complement System Dysregulation in Neurodegeneration - Research Gap rel 7.20

COMPLEMENT["COMPLEMENT"] -->|"associated with"| Complement["Complement"] COMPLEMENT["COMPLEMENT"] -->|"regulates"| Complement

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Wiki CR1 Gene — Complement Component 1q Receptor rel 7.10

Complement["Complement"] CR1 -->|"associated with"| Complement CLU["CLU"] CLU -->|"regulates

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Wiki Complement Inhibitor Therapy in Neurodegeneration rel 6.80

Complement System Biology in Neurodegeneration ### The Complement Cascade The complement

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Wiki Complement Pathway Inhibition Therapy for Neurodegeneration rel 6.80

COMPLEMENT["COMPLEMENT"] -->|"associated with"| Complement["Complement"] COMPLEMENT["COMPLEMENT"] -->|"regulates"| Complement

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Wiki C1QA Gene — Complement Component 1q A Chain rel 6.70

complement appears bidirectional: tau pathology activates complement, and complement activation

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Wiki C1S Gene rel 6.70

complement overactivation - Renal involvement via complement-mediated injury ## Complement System

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Hypothesis Complement Cascade Activation Bridges Microglial OxPC Sensing to Synaptic Vulnerability rel 6.70

complement cascade)` and the pathway label is `Classical complement cascade

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Wiki Complement System Therapeutics for Neurodegeneration rel 6.20

COMPLEMENT["COMPLEMENT"] -->|"associated with"| Complement["Complement"] COMPLEMENT["COMPLEMENT"] -->|"regulates"| Complement

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Hypothesis Complement C1q Suppression as Mechanism Linking Exercise Plasma to PV Interneuron Protection rel 6.20

complement inhibitors target C5 or C3. Identifier COMPLEMENT_LANDSCAPE. 3. C1q has non-complement

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Wiki C2 Protein rel 5.70

Complement Component 2 C2 Protein [@complement2019] Protein Name Complement Component

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Hypothesis Complement C1QA Spatial Gradient in Cortical Layers rel 5.70

complement functions in deeper cortical layers (where complement aids debris

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Wiki c6 rel 5.60

Complement Component 6) encodes a terminal complement protein that is essential

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Wiki Validated Hypothesis: Complement Cascade Inhibition Synaptic Protection rel 5.60

Complement Cascade Inhibition Synaptic Protection Mechanism of Action The complement

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Wiki cfh-protein rel 5.20

Complement Factor H - [Complement System](/mechanisms/complement-system) — Overview of complement activation

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Wiki C4B Gene rel 4.90

Complement Component 4B) encodes a crucial protein in the complement

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Hypothesis Complement Cascade Inhibition Synaptic Protection rel 4.90

Complement Cascade Inhibition Synaptic Protection Mechanism of Action The complement

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