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All 7 Hypotheses 1 Papers 1 Wikis 1 Gaps 1 Colliders 0 Debates 1 Bounties 0 Missions 1 Work packets 1 Genes 0 Diseases 0 Phenotypes 0 Gene ontology 0

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30 results

Wiki Validated Hypothesis: ACSL4-Driven Ferroptotic Priming in Disease-Associated Microglia rel 4.20

microglia and not observed in homeostatic microglia, astrocytes, or neurons

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Wiki Validated Hypothesis: 40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Priming to Selectively Eliminate Disease-Associated Microglia rel 4.00

microglia and not observed in homeostatic microglia, astrocytes, or neurons

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Hypothesis HK2-Dependent Metabolic Checkpoint as the Gatekeeper of DAM Transition rel 3.60

microglia to disease-associated microglia (DAM). This transition involves complex

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Wiki Validated Hypothesis: TREM2-Mediated Astrocyte-Microglia Crosstalk in Neurodegeneration rel 3.50

Microglia Crosstalk in Neurodegeneration > **Status**: ✅ Validated | **Composite Score

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Wiki Validated Hypothesis: TREM2-APOE Axis Dissociation for Selective DAM Activation rel 3.40

Microglia cluster 1 ("homeostatic microglia"), co-expressing canonical markers including

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Wiki Validated Hypothesis: Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming in Neurodegeneration rel 3.20

microglia; low in neurons and astrocytes - NLRP3 expression increases 3-5× in AD microglia

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Wiki Validated Hypothesis: Prime Editing Precision Correction of APOE4 to APOE3 in Microglia rel 3.20

Microglia (significant, upregulated in disease-associated microglia) - Choroid plexus epithelium

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Hypothesis CSF1R Inhibition-Mediated Microglial Replacement as a State Transition Reset rel 3.10

microglia, with the highest expression in microglia bordering degenerating motor

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Hypothesis P2RY12-mediated cerebral VSMC dysfunction establishes a vicious cycle with microglial P2RY12 activation rel 3.00

microglia) within the disease context of neurodegeneration can redirect a disease

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Hypothesis TREM2-APOE Axis Dissociation for Selective DAM Activation rel 3.00

Microglia cluster 1 ("homeostatic microglia"), co-expressing canonical markers including

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Hypothesis TREM2 R47H Metabolic Lock-in at Cholesterol Ester Accumulation rel 2.70

microglia. Transcriptomic analyses of R47H iPSC-derived microglia demonstrate impaired

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Hypothesis TREM2 Agonism to Restore Microglial Phagocytosis Across Both Pathologies rel 2.70

microglia in the central nervous system, functioning as a master

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Wiki Validated Hypothesis: SASP-Mediated Complement Cascade Amplification rel 2.70

microglia (SEA-AD single-cell data, disease-associated microglia cluster

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Wiki Validated Hypothesis: ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drives White Matter Degeneration in Alzheimer's Disease rel 2.60

microglia and not observed in homeostatic microglia, astrocytes, or neurons

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Hypothesis Selective Microglial Senescence Targeting via TREM2 Modulation rel 2.50

microglia stems from the observation that aged or dysfunctional microglia

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Wiki Validated Hypothesis: Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 Proteinopathy Neuroinflammation in ALS/FTD rel 2.50

microglia; low in neurons and astrocytes - NLRP3 expression increases 3-5× in AD microglia

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Wiki Validated Hypothesis: Mitochondrial DAMPs-Driven AIM2 Inflammasome Activation in Neurodegeneration rel 2.40

microglia; low in neurons and astrocytes - NLRP3 expression increases 3-5× in AD microglia

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Wiki Validated Hypothesis: SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senescence rel 2.20

microglia **Hypothesis Type**: mechanistic **Mechanism Category**: neuroinflammation **Validation Date**: 2026-04-29 **Debates

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Hypothesis Temporal SPP1 Inhibition During Critical Windows rel 2.10

microglia (DAM) and aging-associated microglia. ### Animal Model Evidence Genetic

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Hypothesis TREM2-mediated microglial tau clearance enhancement rel 2.10

microglia. They showed that TREM2-deficient microglia exhibited reduced uptake

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Wiki Validated Hypothesis: Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-Synuclein Aggregates Drives Non-Cell-Autonomous Neurodegeneration rel 2.10

microglia; low in neurons and astrocytes - NLRP3 expression increases 3-5× in AD microglia

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Wiki Validated Hypothesis: Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Release Mechanism for AIM2 Inflammasome Activation in Neurodegeneration rel 2.10

microglia; low in neurons and astrocytes - NLRP3 expression increases 3-5× in AD microglia

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Hypothesis TREM2-Mediated Oligodendrocyte-Microglia Signaling in White Matter Neurodegeneration rel 2.00

microglia signaling axis represents a sophisticated cellular communication network essential

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Hypothesis Severely Depleted mtDNA and Impaired OXPHOS Defines Senescent Microglia rel 2.00

Microglia starts from the claim that Senescent microglia exhibit cumulative

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Hypothesis TREM2-Senescence Cascade in Astrocyte-Microglia Communication Breakdown rel 1.90

microglia communication networks. Healthy TREM2+ microglia communicate threat status to astrocytes

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Hypothesis Palmitoylethanolamide-Based Endocannabinoid Therapy rel 1.90

microglia reveals that aged microglia show reduced PPARA expression, potentially

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Hypothesis CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macrophages, Triggering NF-κB-Dependent SPP1 Transcription rel 1.80

microglia" phenotype — activated microglia with processes that encircled synapses and Aβ plaques

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Hypothesis Epigenetic Bivalency at CDKN2A Locus Distinguishes Senescent from Activated Microglia rel 1.80

Microglia starts from the claim that modulating CDKN2A, H3K9me3, DREAM

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Hypothesis CSF1R Inhibition Reversal Window Depends on Microglia Replacement Kinetics rel 1.80

Microglia Replacement Kinetics starts from the claim that modulating CSF1R

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Hypothesis Persistent γH2AX+53BP1 Foci with DREAM Complex Activation Defines Irreversibly Arrested Microglia rel 1.70

Microglia starts from the claim that Senescent microglia accumulate persistent

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Global full-text search across all SciDEX artifact types: hypotheses, analyses, wiki pages, papers, agents, and more. Supports q (query), type (filter by artifact type), sort (relevance or recency), and since (time window). Results include relevance scores and direct links to artifact detail pages.

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