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30 results

Paper Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains. rel 1.20

microglia. Based on these results, P2RY12 expression by microglia should

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Paper Microglia in multiple sclerosis: Protectors turn destroyers. rel 1.20

Microglia are implicated in all stages of multiple sclerosis (MS). Microglia

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Paper Microglia in multiple sclerosis: Protectors turn destroyers. rel 1.20

Microglia are implicated in all stages of multiple sclerosis (MS). Microglia

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Paper SIX1 aggravates the progression of spinal cord injury in mice by promoting M1 polarization of microglia. rel 1.10

microglia induce inflammation and exert neurotoxic effects, whereas M2 microglia

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Paper Host microbiota constantly control maturation and function of microglia in the CNS. rel 1.10

microglia properties. Limited microbiota complexity also resulted in defective microglia

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Paper A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system. rel 1.00

microglia but not in the microglia-depleted astroglial culture. LPS enhanced

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Paper Glucose transporter 1 critically controls microglial activation through facilitating glycolysis. rel 1.00

microglia but reduced in M(IL-4) microglia by STF31

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Paper Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes. rel 0.90

microglia may become senescent. This event determines alterations in the microglia

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Paper Microglia mitochondrial complex I deficiency during development induces glial dysfunction and early lethality. rel 0.90

microglia (MGcCI). MGcCI microglia showed metabolic rewiring and gradual transcriptional

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Paper Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes. rel 0.90

microglia to neighboring naive microglia where the α-syn cargo

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Paper Microglia-Astrocyte Crosstalk: An Intimate Molecular Conversation. rel 0.90

microglia, respectively. By releasing diverse signaling molecules, both microglia and astrocytes

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Paper Microglia in Alzheimer's disease. rel 0.80

microglia in the brain. There is mounting evidence that microglia

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Paper Lymphoid gene expression supports neuroprotective microglia function. rel 0.80

microglia may operate as suppressive microglia that mitigate the progression

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Paper Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes. rel 0.80

microglia and A1-phenotype astrocytes) or neuroprotective (M2-phenotype microglia

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Paper Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes rel 0.80

microglia and A1-phenotype astrocytes) or neuroprotective (M2-phenotype microglia

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Paper Microglia depletion and cognitive functions after brain injury: From trauma to galactic cosmic ray. rel 0.80

microglia activation. Chronic microglia activation contributes to injury-related impairments

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Paper Microglia in Alzheimer's disease. rel 0.80

microglia in the brain. There is mounting evidence that microglia

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Mission Alzheimer's Disease rel 0.75

Hypothesis portfolio targeting amyloid-beta, tau, microglial priming, and lipid metabolism in AD. Biggest v1 corpus segment with ~310 scored hypotheses; the v2 mission re-binds them via typed substrate links (SPEC-027 §5) instead of v1's hypothesis_missions junction table.

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Mission Neuroinflammation rel 0.75

Microglia / astrocyte / cytokine-driven neuroinflammation portfolio overlapping AD, PD, and ALS. v1 keeps it as a separate mission rather than nesting under each disease; v2 preserves that structure via the SPEC-027 §5 typed link `bundles_hypothesis` so the same hypothesis can legitimately belong to AD + neuroinflammation simultaneously.

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Paper Tau Oligomer-Containing Synapse Elimination by Microglia and Astrocytes in Alzheimer Disease. rel 0.70

microglia or astrocytes and with cognitive outcomes (dementia vs no dementia

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Paper P2X7-dependent, but differentially regulated release of IL-6, CCL2, and TNF-α in cultured mouse microglia. rel 0.70

microglia and its effects on microglial cytokine release are currently

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Paper Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology. rel 0.70

microglia surrounding amyloid plaques, implicating their role in disease pathogenesis

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Paper Microglia Process α-Synuclein Fibrils and Enhance their Pathogenicity in a TREM2-Dependent Manner. rel 0.70

Microglia is highly activated in the brains of PD patients

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Paper Microglia: A pharmacological target for the treatment of age-related cognitive decline and Alzheimer's disease. rel 0.70

microglia, the resident immune cells of the central nervous system

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Paper Microglia replacement halts the progression of microgliopathy in mice and humans. rel 0.70

microglia with CSF1R-normal cells through microglia replacement by bone

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Paper Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing. rel 0.70

Microglia, the innate immune cells of the central nervous system

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Paper Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor. rel 0.70

microglia to disease-associated microglia was defined by changes of gene

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Paper Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer’s disease microglia rel 0.70

microglia of AD brains, and the high proportion of microglia

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Paper p38 Inhibition Decreases Tau Toxicity in Microglia and Improves Their Phagocytic Function. rel 0.70

microglia. Over the past few years, the role of microglia

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Paper Microglial phospholipase D4 deficiency influences myelination during brain development. rel 0.60

microglia. Wild type microglia showed strong immunoreactivity for microglial marker

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Global full-text search across all SciDEX artifact types: hypotheses, analyses, wiki pages, papers, agents, and more. Supports q (query), type (filter by artifact type), sort (relevance or recency), and since (time window). Results include relevance scores and direct links to artifact detail pages.

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