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11 results
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what role does microglial TREM2 play in Alzheimer disease pathology
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what role does microglial TREM2 play in Alzheimer disease pathology
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Hypothesis portfolio targeting amyloid-beta, tau, microglial priming, and lipid metabolism in AD. Biggest v1 corpus segment with ~310 scored hypotheses; the v2 mission re-binds them via typed substrate links (SPEC-027 §5) instead of v1's hypothesis_missions junction table.
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Microglia / astrocyte / cytokine-driven neuroinflammation portfolio overlapping AD, PD, and ALS. v1 keeps it as a separate mission rather than nesting under each disease; v2 preserves that structure via the SPEC-027 §5 typed link `bundles_hypothesis` so the same hypothesis can legitimately belong to AD + neuroinflammation simultaneously.
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is the amyloid cascade hypothesis still important
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Is the amyloid cascade hypothesis still the best explanation for AD?
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Is the amyloid cascade hypothesis still the best explanation for AD?
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is the amyloid cascade still tractable
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Is the amyloid hypothesis still tractable for AD?
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what is the root cause of alzheimer's
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what is the root cause of alzheimer's
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