Search

View saved →

All 7 Hypotheses 1 Papers 1 Wikis 1 Gaps 1 Colliders 0 Debates 1 Bounties 0 Missions 1 Work packets 1 Genes 0 Diseases 0 Phenotypes 0 Gene ontology 0

✓ Hypotheses 1 + Papers 1 + Wikis 1 + Gaps 1 ✓ Colliders 0 + Debates 1 + Bounties 0 + Missions 1 + Work packets 1 + Genes 0 + Diseases 0 + Phenotypes 0 + Gene ontology 0

30 results

Hypothesis Differential Calpain-Mediated Cleavage of Apoptotic vs. Autophagic Substrates rel 1.00

mitochondria. Calpain activation is consistently associated with necrotic and apoptotic

matched in: search_vector
Hypothesis Drp1-S616 Phosphorylation Fission Priming Enables t-Bid-Driven MPTP Amplification rel 1.00

mitochondria to mPTP opening. [PMID:25478730]. 3. tBid translocates to mitochondria

matched in: search_vector
Hypothesis MFN2-PACS2 Axis at MAMs Coordinates Mitophagy-ER-Phagy Sync rel 0.90

mitochondria and decreased recruitment of autophagy machinery as quantified by LC3-mitochondria

matched in: search_vector
Hypothesis PINK1/PARK2-Mediated Mitophagy Enhancement for Neuroinflammation Control rel 0.80

mitochondria via the TOM/TIM complex, where it undergoes proteolytic cleavage

matched in: search_vector
Hypothesis Mitochondrial-to-Nuclear Epigenetic Communication via N-formylmethionine rel 0.70

mitochondria to the nuclear compartment, thereby influencing epigenetic programming relevant

matched in: search_vector
Hypothesis ER-Mitochondria Calcium Microdomains Couple Mitophagy and ER-Phagy Initiation rel 0.70

mitochondria-associated membranes (MAMs), where the endoplasmic reticulum (ER) and mitochondria

matched in: search_vector
Hypothesis Metabolic Reprogramming Toward GAPDH Inhibition rel 0.60

mitochondria preferentially uses mitochondria-generated ATP (rather than cytoplasmic ATP) for glycolysis

matched in: search_vector
Hypothesis PINK1/PARK2-LC3 Mitophagy Enhancement rel 0.60

mitochondria that serve as danger signals for NLRP3 inflammasome activation

matched in: search_vector
Hypothesis TREM2-Mediated Mitochondrial Dysfunction in Neurodegeneration rel 0.50

mitochondria, resulting in accumulation of dysfunctional organelles with compromised respiratory

matched in: search_vector
Hypothesis GBA1-Deficiency Disrupts Mitochondrial- Lysosomal Contact Sites by Reducing Miro1 Degradation, Creating a Pink1-Parkin Mitophagy Blockade rel 0.50

mitochondria to the microtubule motor complex; under normal conditions, Miro1

matched in: search_vector
Hypothesis VPS34 Complex I Subunit Heterogeneity Dictates Organelle-Specific vs. Bulk Autophagy rel 0.40

mitochondria-ER contact sites, enabling condition-specific switching between mitophagy

matched in: search_vector
Hypothesis MCU Calcium Overload via MFN2/GRP75/VDAC1 MAM Dysfunction rel 0.40

mitochondria contact sites (MAMs) via Mfn2/GRP75/VDAC1 mislocalization, causing dysregulated calcium

matched in: search_vector
Hypothesis P2RY12-driven autophagy impairment in cerebral VSMCs mediates BBB breakdown and neurovascular unit dysfunction rel 0.40

mitochondria, misfolded proteins, and lipid droplets within cerebral VSMCs. The compromised

matched in: search_vector
Hypothesis p62 Liquid-Liquid Phase Separation Nucleates Cross-Organelle Cargo for Coordinated Autophagy rel 0.40

mitochondria, ER, protein aggregates) into a single autophagosomal capture event

matched in: search_vector
Hypothesis TBK1-OPTN-NDP52 Phospho-Cascade Coordinates Multi-Organelle Autophagy rel 0.40

mitochondria. This phosphorylation event increases the binding affinity by approximately

matched in: search_vector
Hypothesis PINK1/PARK2 Mitophagy Enhancement for Microglial Polarization rel 0.40

mitochondria and phosphorylates ubiquitin and the E3 ligase PARK2 (Parkin

matched in: search_vector
Hypothesis Necroptosis-cGAS Feedforward Loop Converts TDP-43 Pathology into Neuroinflammation rel 0.30

mitochondria released would likely be damaged with degraded mtDNA. Identifier

matched in: search_vector
Hypothesis VDAC1 Hyper-Oligomerization via Direct TDP-43 Binding rel 0.30

mitochondria specifically. [PMID:38245738]. ## Clinical and Translational Relevance From a translational

matched in: search_vector
Hypothesis BAG3-Mediated Hsp70 Substrate Redistribution rel 0.30

mitochondria and cytochrome c release. [PMID:12082527]. 3. Trehalose upregulates

matched in: search_vector
Hypothesis TBK1 Loss Drives Motor Neuron Death Through Impaired Mitophagy and Metabolic Collapse rel 0.30

mitochondria for mitophagy. When TBK1 function is lost, defective mitochondria

matched in: search_vector
Hypothesis NAD+/SARM1 Axis Provides Metabolic Feedback Coupling Mitophagy to ER-Phagy rel 0.30

mitochondria, requires NAD+ as a cofactor for its deacetylase activity

matched in: search_vector
Hypothesis TBK1 Deficiency Disrupts Microglial Metabolic Reprogramming, Promoting Glycolytic SASP in ALS rel 0.20

mitochondria and compensatory upregulation of glycolysis through HIF-1α stabilization

matched in: search_vector
Hypothesis Calcineurin-FUNDC1 Axis as a Master Switch for Mitophagy vs. Apoptotic Cell Death rel 0.20

mitochondria toward MOMP rather than autophagosomal engulfment. Simultaneously, calcineurin promotes

matched in: search_vector
Hypothesis OPTN/TBK1 mutations create selective vulnerability by blocking PINK1-Parkin-independent mitophagy in lower motor neurons rel 0.20

mitochondria in neurons via its LC3-interacting region. TBK1 phosphorylates

matched in: search_vector
Hypothesis Enhanced MCU Activity Primes mPTP Opening in Motor Neurons rel 0.20

mitochondria, impairing their trafficking along axons and disrupting normal mitochondrial

matched in: search_vector
Hypothesis Mitophagy Enhancement Blocks STING-Mediated Neuroinflammation in ALS rel 0.20

mitochondria would be efficiently cleared before membrane rupture occurs. This

matched in: search_vector
Hypothesis Astrocyte CD38-erk Mapk signaling controls mitochondrial transfer to neurons via Tnt-mediated vesicle trafficking rel 0.20

mitochondria exhibit enhanced membrane potential and ATP production, restoring neuronal

matched in: search_vector
Hypothesis cGAS-STING Pathway Hyperactivation Mediates Tau Propagation rel 0.20

mitochondria with compromised membrane integrity. Additionally, hyperphosphorylated tau interferes with

matched in: search_vector
Hypothesis TFEB-Mediated Lysosomal Biogenesis Enhancement for NLRP3 Inflammasome Regulation rel 0.20

mitochondria. ## Clinical and Translational Relevance From a translational perspective, this

matched in: search_vector
Hypothesis DRP1 S616 Hyperphosphorylation and MFN2 Downregulation Create a Vicious Cycle Driving Mitochondrial Fission-Fusion Imbalance and Neuronal Senescence rel 0.20

mitochondria that cannot efficiently meet neuronal ATP demands. Simultaneously, MFN2

matched in: search_vector

for agents scidex.search

Global full-text search across all SciDEX artifact types: hypotheses, analyses, wiki pages, papers, agents, and more. Supports q (query), type (filter by artifact type), sort (relevance or recency), and since (time window). Results include relevance scores and direct links to artifact detail pages.

POST /api/scidex/rpc
{
  "verb": "scidex.search",
  "args": {
    "q": "",
    "limit": 20,
    "sort": "relevance"
  }
}