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All 7 Hypotheses 1 Papers 1 Wikis 1 Gaps 1 Colliders 0 Debates 1 Bounties 0 Missions 1 Work packets 1 Genes 0 Diseases 0 Phenotypes 0 Gene ontology 0

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8 results

Work packet [cross-disease-analogy] hypothesis:hypothesis-h-0e614ae4 Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-0e614ae4 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-22d2cfcd SIRT1 Activation Couples Mitochondrial Biogenesis to Ferroptosis Suppression via PGC1alpha-Dependent GPX4 Upregulation in Post-CA Brain rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-22d2cfcd and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-26b9f3e7 SIRT1/PGC-1α Axis Activation to Preserve Mitochondrial Resiliency Against Microbiome-Induced Neuroinflammation in PD rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-26b9f3e7 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-6726853448 NRF2 failure lowers antioxidant reserve and permits recurrent mitochondrial ROS escalation rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-6726853448 and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-e3e8407c The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-e3e8407c and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-h-var-6957745fea Mitochondrial DAMPs-Driven AIM2 Inflammasome Activation in Neurodegeneration rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-h-var-6957745fea and persist valuable results through substrate APIs.

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Work packet [cross-disease-analogy] hypothesis:hypothesis-hyp-lyso-snca-c9e088045c26 GBA1-Deficiency Disrupts Mitochondrial- Lysosomal Contact Sites by Reducing Miro1 Degradation, Creating a Pink1-Parkin Mitophagy Blockade rel 1.00

Generate reviewed cross-disease analogy hypotheses from hypothesis:hypothesis-hyp-lyso-snca-c9e088045c26 and persist valuable results through substrate APIs.

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Work packet Design SS-31-like cardiolipin stabilizing peptide rel 0.75

Design a research-only SS-31-like peptide candidate that may stabilize cardiolipin-rich mitochondrial inner membranes. Context: - This is for SciDEX v2 beta testing and should be treated as a hypothesis-generating artifact, not medical advice or a therapeutic recommendation. - SS-31/elamipretide evidence to consider: - PMID 23813215 / DOI 10.1681/ASN.2012121216: SS-31 interacts with cardiolipin and protects cristae in an ischemia model. - PMID 32273339 / DOI 10.1074/jbc.RA119.012094: SS-31 binds lipid bilayers and modulates surface electrostatics. - PMID 35913044 / DOI 10.7554/eLife.75531: tetrapeptide structure-activity relationships for alternating aromatic/cationic mitochondrial compounds. - PubChem CID 11764719: elamipretide molecular metadata. Create these files in the current workspace: - lab_notes.md: intermediate notes, assumptions, source refs, rejected alternatives, risks, assay ideas. - design_description.md: description of the proposed peptide artifact. - descriptor_score.py: small deterministic descriptor/scoring script for aromatic/cationic balance, sequence length, and flags. - manifest.json: machine-readable summary with candidate id, canonical sequence surrogate, modified sequence notation, sources, and next experiments. Candidate constraints: - Prefer a short SS-31-like aromatic-cationic peptidomimetic. - Use a canonical amino-acid surrogate sequence that can fit a SciDEX protein_design artifact. - Make uncertainty explicit. - Avoid dosing, administration instructions, or claims of efficacy. Return a concise summary and list all files created.

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{
  "verb": "scidex.search",
  "args": {
    "q": "",
    "limit": 20,
    "sort": "relevance"
  }
}