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30 results

  • Wiki Kinevo Inc. rel 0.28

    mitochondrial-dysfunction) - [Mitochondrial Dysfunction in Parkinson's](/diseases/parkinsons-disease#mitochondrial-dysfunction

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  • Wiki Progressive Myoclonic Epilepsies (PME) rel 0.27

    dysfunction](/mechanisms/lysosomal-dysfunction), [mitochondrial-dysfunction](/mechanisms/mitochondrial-dysfunction), and neuronal death [@lalioti]. [@joensuu

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  • Wiki HIV-Associated Neurocognitive Disorders (HAND) rel 0.20

    mitochondrial-dysfunction](/mechanisms/mitochondrial-dysfunction) in [neurons](/entities/neurons), and activates [microglia](/cell-types/microglia

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  • Wiki Cockayne Syndrome rel 0.20

    mitochondrial-dysfunction](/mechanisms/mitochondrial-dysfunction)**: The role of mitochondrial impairment in CS pathogenesis

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  • Wiki LRRK2 Kinase Inhibitors rel 0.11

    dysfunction, hyperactive LRRK2 kinase activity contributes to: - **[mitochondrial-dysfunction](/mechanisms/mitochondrial-dysfunction

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  • Wiki Lysosomal Dysfunction in Neurodegeneration rel 0.11

    dysfunction hinders the autophagic clearance of damaged mitochondria (mitophagy), leading to further mitochondrial

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  • Wiki mitochondrial-dynamics rel 0.10

    dysfunction in AD (n.d.) 17. Unknown, - parkinsons — PINK1/Parkin mitophagy pathway (n.d.) 18. Unknown, - huntington-pathway — mHTT disrupts mitochondrial dynamics (n.d.) 19. Unknown, - als — Motor neuron

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  • Wiki ion-channel-dysfunction-neurodegeneration rel 0.10

    mitochondrial-dysfunction|Mitochondrial Dysfunction]] - [[NMDA-receptor|NMDA Receptor]] - [[voltage-gated

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  • Wiki gm1-gangliosidosis rel 0.10

    mitochondrial-dysfunction](/mechanisms/mitochondrial-dysfunction)**: Impaired oxidative phosphorylation, reduced ATP production, and increased

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  • Wiki Locus Coeruleus Neurons in Alzheimer's Disease rel 0.10

    mitochondrial-dysfunction---energy-metabolism ###-risk-genes --apoe---major-ad-risk

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  • Wiki NRF2 — Nuclear Factor Erythroid 2-Related Factor 2 rel 0.10

    mitochondrial-dysfunction](/mechanisms/mitochondrial-dysfunction), and [neuroinflammation](/mechanisms/neuroinflammation) [@contribution2021][@reinforcing2025]. Pharmacological NRF2

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  • Wiki prefrontal-cortex rel 0.10

    mitochondrial-dysfunction, oxidative-stress, and energy failure 3. **Dopaminergic vulnerability

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  • Wiki Cerebral Small Vessel Disease rel 0.10

    mitochondrial-dysfunction - Oligodendrocyte death and demyelination - Axonal damage and white

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  • Wiki Huntingtin Protein (HTT) rel 0.10

    mitochondrial-dysfunction ### Impaired BDNF Signaling mHTT reduces neurotrophic support to striatal

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  • Wiki X-Linked Adrenoleukodystrophy (X-ALD) rel 0.10

    mitochondrial-dysfunction in axons - Oxidative damage and energy failure - Secondary

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  • Wiki cingulate-cortex rel 0.10

    mitochondrial-dysfunction ## External Links - [Allen Human Brain Atlas — Cingulate Cortex

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  • Wiki Presenilin-2 (PS2) rel 0.10

    mitochondrial-dysfunction, opening of the permeability transition pore, and apoptosis

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  • Wiki Olfactory Bulb rel 0.10

    mitochondrial-dysfunction ## External Links - [Allen Human Brain Atlas — Olfactory Bulb

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  • Wiki er-stress-neurodegeneration rel 0.10

    mitochondrial-dysfunction](/mechanisms/mitochondrial-dysfunction). [lrrk2](/proteins/lrrk2-protein) mutations, the most common genetic

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  • Wiki hereditary-spastic-paraplegia rel 0.10

    mitochondrial-dysfunction | mitophagy - lysosomal-dysfunction | Lipid Dysregulation - Cortical Pyramidal [neurons

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  • Wiki Menkes Disease rel 0.10

    mitochondrial-dysfunction](/mechanisms/mitochondrial-dysfunction)**: Shared mechanism of impaired energy metabolism - **[oxidative

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  • Wiki Caspase-3 (CASP3) rel 0.10

    mitochondrial-dysfunction](/mechanisms/mitochondrial-dysfunction) - Caspase-3-cleaved tau (TauC3) is an early

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  • Wiki Norepinephrine (Noradrenaline) rel 0.10

    mitochondrial-dysfunction](/mechanisms/mitochondrial-dysfunction) [@kay2025] - **Autonomous pacemaker activity**: LC [neurons](/entities/neurons

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  • Wiki Leber Hereditary Optic Neuropathy (LHON) rel 0.10

    mitochondrial-dysfunction](/mechanisms/mitochondrial-dysfunction) leads to neuronal death in [neurodegenerative diseases

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  • Wiki tofersen rel 0.10

    mitochondrial-dysfunction](/mechanisms/mitochondrial-dysfunction), and [protein-aggregation](/mechanisms/protein-aggregation) [@miller2022] [@benatar2022] ### Neurofilament

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  • Wiki Globus Pallidus rel 0.10

    mitochondrial-dysfunction and oxidative-stress - **Iron content**: The globus pallidus

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  • Wiki Motor Cortex rel 0.10

    mitochondrial-dysfunction 3. **Glutamate excitotoxicity**: Betz cells receive dense glutamatergic

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  • Wiki Molecular Chaperones in Neurodegeneration rel 0.10

    mitochondrial-dysfunction](/mechanisms/mitochondrial-dysfunction)[@saxena2025]. Mutations in HSPD1 cause hereditary spastic

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  • Wiki Sphingolipid Metabolism in Neurodegeneration rel 0.10

    mitochondrial-dysfunction](/mechanisms/mitochondrial-dysfunction), and [oxidative-stress](/mechanisms/oxidative-stress) 2,4. ### Complex

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  • Wiki Cdk5 (Cyclin-Dependent Kinase 5) rel 0.10

    mitochondrial-dysfunction](/mechanisms/mitochondrial-dysfunction) via [drp1](/proteins/drp1) phosphorylation ### ALS In [als](/diseases/amyotrophic-lateral-sclerosis

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