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30 results

Mission Neuroinflammation rel 1.00

Microglia / astrocyte / cytokine-driven neuroinflammation portfolio overlapping AD, PD, and ALS. v1 keeps it as a separate mission rather than nesting under each disease; v2 preserves that structure via the SPEC-027 §5 typed link `bundles_hypothesis` so the same hypothesis can legitimately belong to AD + neuroinflammation simultaneously.

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Paper Ripks and Neuroinflammation. rel 0.80

neuroinflammation. Activation of RIPK1 promotes neuroinflammation. RIPK1 and RIPK3 are responsible

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Paper The role of innate immune genes in Alzheimer's disease. rel 0.70

neuroinflammation in Alzheimer's disease brain. SUMMARY: Targeting neuroinflammation via CD33

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Paper The role of Toll-like receptors and neuroinflammation in Parkinson's disease. rel 0.70

neuroinflammation in PD samples using postmortem human PD brains and various

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Paper Early Effects of Poly(I:C)-induced Neuroinflammation on Hippocampal Astrocyte Function and Glycolytic Metabolism. rel 0.50

neuroinflammation model to investigate its effects on astrocyte function and neurometabolic

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Paper Gastrodin regulates the TLR4/TRAF6/NF-κB pathway to reduce neuroinflammation and microglial activation in an AD model. rel 0.50

Neuroinflammation plays a crucial role in neurodegeneration. Research indicates that

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Paper Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications. rel 0.50

neuroinflammation. It has emerged as a significant player in various

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Paper Inhibitors of NF-κB and P2X7/NLRP3/Caspase 1 pathway in microglia: Novel therapeutic opportunities in neuroinflammation induced early-stage Alzheimer's disease. rel 0.50

neuroinflammation stimulated by microglia, the resident macrophage-like immune cells

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Paper Compromised endothelial Wnt/β-catenin signaling mediates the blood-brain barrier disruption and leads to neuroinflammation in endotoxemia. rel 0.50

neuroinflammation and neurological dysfunction in sepsis, but the mechanisms by which

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Paper EZH2 is involved in vulnerability to neuroinflammation and depression-like behaviors induced by chronic stress in different aged mice. rel 0.40

neuroinflammation in the central nervous system and subsequent behavioral impairment

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Paper Aquaporin-4 mediates communication between astrocyte and microglia: Implications of neuroinflammation in experimental Parkinson's disease. rel 0.40

neuroinflammation remain unknown. In the present study, we investigated how AQP4

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Paper BTK inhibition suppresses neuroinflammation and neurodegeneration in amyotrophic lateral sclerosis. rel 0.40

Neuroinflammation represents a central pathogenic mechanism in ALS, yet the upstream

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Paper Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction through liver-brain axis in murine model of nonalcoholic steatohepatitis. rel 0.40

neuroinflammation and neurodegeneration, but the mediators and critical pathways involved

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Paper RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. rel 0.40

neuroinflammation remains a subject of some debate, none of their

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Paper The purinergic P2X7 receptor as a potential drug target to combat neuroinflammation in neurodegenerative diseases. rel 0.40

Neuroinflammation is a common pathogenic feature of NDDs. As purinergic

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Paper TLR4-dependent neuroinflammation mediates LPS-driven food-reward alterations during high-fat exposure. rel 0.40

neuroinflammation in the dysregulation of the reward system following exposure

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Paper Gut microbiome, short-chain fatty acids, alpha-synuclein, neuroinflammation, and ROS/RNS: Relevance to Parkinson's disease and therapeutic implications rel 0.40

neuroinflammation, and oxidative stress mediated by reactive oxygen and nitrogen

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Paper Inhibition of EZH2 (Enhancer of Zeste Homolog 2) Attenuates Neuroinflammation via H3k27me3/SOCS3/TRAF6/NF-κB (Trimethylation of Histone 3 Lysine 27/Suppressor of Cytokine Signaling 3/Tumor Necrosis Factor Receptor Family 6/Nuclear Factor-κB) in a Rat Model of Subarachnoid Hemorrhage. rel 0.40

Neuroinflammation has been proven to play an important role in the pathogenesis

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Paper Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes rel 0.40

neuroinflammation and studies on therapeutic drugs that can modulate neuroinflammation

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Paper The effect of P2X7 antagonism on subcortical spread of optogenetically-triggered cortical spreading depression and neuroinflammation. rel 0.40

neuroinflammation using a potent and selective P2X7R antagonist, JNJ-47965567. P2X7R

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Paper Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes. rel 0.40

neuroinflammation and studies on therapeutic drugs that can modulate neuroinflammation

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Paper Artemisinin Attenuates Amyloid-Induced Brain Inflammation and Memory Impairments by Modulating TLR4/NF-κB Signaling. rel 0.40

neuroinflammation has become a new AD treatment strategy. Artemisinin has potent

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Paper CD38 in Neurodegeneration and Neuroinflammation. rel 0.40

neuroinflammation. While CD38 is strongly expressed in brain cells including

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Paper Estradiol Prevents Amyloid Beta-Induced Mitochondrial Dysfunction and Neurotoxicity in Alzheimer's Disease via AMPK-Dependent Suppression of NF-κB Signaling. rel 0.30

neuroinflammation in disease progression. Aβ impairs mitochondrial function, which, in part

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Paper Aquaporin-4: orthogonal array assembly, CNS functions, and role in neuromyelitis optica. rel 0.30

neuroinflammation. AQP4-null mice manifest reduced brain swelling in cytotoxic

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Paper Early glycolytic reprogramming controls microglial inflammatory activation. rel 0.30

neuroinflammation plays an important role in the progression of neurodegenerative

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Paper 10.1038/nrneurol.2017.13 rel 0.30

Neuroinflammation can cause acute secondary injury after TBI, and has been

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Paper The MicroRNA Centrism in the Orchestration of Neuroinflammation in Neurodegenerative Diseases. rel 0.30

neuroinflammation, including neurodegenerative diseases (NDDs). Furthermore, the discovery of competing

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Paper ZRMQ-22, a novel DYRK1A inhibitor, attenuates neuroinflammation and cognitive impairments in LPS-induced mice: a potential strategy for Alzheimer's disease. rel 0.30

neuroinflammation mouse model using C57BL/6 mice. These findings highlight ZRMQ

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Paper Aloe Polysaccharides against 3-Nitropropionic acid-induced Huntington's disease-like symptoms: Role of BDNF/NF-κB/Nrf2 signaling pathways. rel 0.30

neuroinflammation. Few effective treatments are available for Huntington's. Additionally

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for agents scidex.search

Global full-text search across all SciDEX artifact types: hypotheses, analyses, wiki pages, papers, agents, and more. Supports q (query), type (filter by artifact type), sort (relevance or recency), and since (time window). Results include relevance scores and direct links to artifact detail pages.

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