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30 results
- Hypothesis Combination Gene Therapy Targeting RGS6 and Parkin or PINK1 to Address Mitochondrial Dysfunction
Parkinson's disease. **Mitochondrial Dysfunction in Parkinson's Disease** Mitochondrial
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Parkinson's disease can redirect a disease-relevant process. The original
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Parkinson's disease can redirect a disease-relevant process. The original
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Parkinson's Disease. PINK1/Parkin-mediated mitophagy generates TFEB-activating signals that
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Parkinson's disease and related synucleinopathies. ## Mechanistic Details: The Presynaptic
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Parkinson's disease, treatment with the ferroptosis inhibitor ferrostatin-1 (Fer-1) at 2 mg/kg
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Parkinson's disease substantia nigra samples from the Parkinson's Progression
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Parkinson's disease, disrupts normal dopaminergic transmission through multiple mechanisms
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Parkinson's disease, and amyotrophic lateral sclerosis. While senolytic approaches
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Parkinson's Disease Models starts from the claim that modulating
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Parkinson's disease attenuated microglial activation and reduced α-synuclein
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Parkinson's disease showed safety and modest motor benefit, but limited
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- Hypothesis Age-Accelerated miR-155 Upregulation Primes Nigral Microglia for Parkinson's Disease Pathology
Parkinson's Disease Pathology starts from the claim that modulating
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Parkinson's disease and related movement disorders. **Molecular Mechanism and Rationale
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- Hypothesis H7: Enteric Nervous System Alpha-Synuclein Propagation Blocker via Gut Barrier Restoration
Parkinson's disease, dementia with Lewy bodies, and multiple system
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- Hypothesis TFEB Activation to Restore Lysosomal Function in Parkinson's Disease Alpha-Synuclein Clearance
Parkinson's disease is characterized by the accumulation of misfolded
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Parkinson's disease represents a priority target given similar HPA axis
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Parkinson's, and Huntington's disease, where protein aggregation is a central
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Parkinson's disease patients, with concentrations reduced to approximately 20-40% of age-matched
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Parkinson's disease (PD), mounting evidence suggests that the enteric
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Parkinson's disease, and amyotrophic lateral sclerosis. While emerging therapeutic
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Parkinson's disease (PD) and other synucleinopathies are characterized by the accumulation
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Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple
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Parkinson's disease, and Huntington's disease. In Alzheimer's disease
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Parkinson's disease, and amyotrophic lateral sclerosis involves compromised oxidative
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- Hypothesis Aryl Hydrocarbon Receptor (AhR) Activation by Microbiome Metabolites Promotes A2 Polarization
Parkinson's disease models, IPA administration attenuates dopaminergic neuron loss
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Parkinson's disease, and frontotemporal dementia. In 5xFAD mice, which
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Parkinson's disease. Quantitative behavioral assays showed improved locomotor function
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Parkinson's disease, schizophrenia, and autism spectrum disorders. This pathological
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Parkinson's Disease**: Reduced expression correlates with alpha-synuclein pathology
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