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All 8 Hypotheses 1 Papers 1 Wikis 1 Gaps 1 Colliders 1 Debates 1 Bounties 0 Missions 1 Work packets 1 Genes 0 Diseases 0 Phenotypes 0 Gene ontology 0

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30 results

Wiki Validated Hypothesis: Inhibiting Heparan Sulfate Proteoglycan Receptor-Mediated Neuronal Tau Uptake rel 8.10

tau pathology, including tau immunotherapy, microtubule-stabilizing agents, and tau

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Wiki Validated Hypothesis: Microglial-Mediated Tau Clearance Dysfunction via TREM2 Signaling rel 7.10

tau aggregates—composed predominantly of MAPT-encoded tau protein in its pathological

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Wiki Validated Hypothesis: LRP1-Dependent Tau Uptake Disruption rel 7.10

tau species, wherein diseased neurons release tau aggregates that are subsequently

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Wiki Validated Hypothesis: Extracellular Vesicle Biogenesis Modulation rel 6.10

tau species between neurons, enabling the propagation of tau aggregates

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Wiki Validated Hypothesis: TREM2-Mediated Microglial Dysfunction Disrupts Perivascular Tau Clearance rel 4.40

tau aggregate degradation. The secondary mechanism involves perivascular tau accumulation

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Wiki Validated Hypothesis: Glymphatic-Mediated Tau Clearance Dysfunction rel 4.30

tau transgenic mice accelerates cognitive decline and increases insoluble tau

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Wiki Validated Hypothesis: Closed-loop tACS targeting EC-II PV interneurons to suppress burst firing and block tau propagation via perforant path in AD rel 4.20

tau pathology in 5XFAD and tau P301S mice. Identifier 31076275. This

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Wiki Validated Hypothesis: Closed-loop tACS targeting EC-II parvalbumin interneurons to restore gamma rhythmogenesis and block tau AIS disruption in AD rel 3.70

tau mouse model, tau pathology was sufficient to produce excitatory

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Wiki Validated Hypothesis: Beta-frequency entrainment therapy targeting PV interneuron-astrocyte coupling for tau clearance rel 3.40

tau tracers (18F-flortaucipir) to assess regional tau burden changes

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Wiki Validated Hypothesis: Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-gamma coupling and prevent tau seeding in AD rel 3.20

tau pathology in 5XFAD and tau P301S mice. Identifier 31076275. This

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Wiki Validated Hypothesis: GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Clearance rel 2.40

Tau Clearance](/wiki/hypotheses-validated-h-var-7c976d9fb7) — score 0.861 - [Microglial-Mediated Tau Clearance Dysfunction

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Wiki Validated Hypothesis: Gamma entrainment therapy to restore hippocampal-cortical synchrony rel 2.10

Tau Pathology Reduction** Emerging evidence shows gamma entrainment reduces tau

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Wiki Validated Hypothesis: MAPT tau seeding and release across AD, FTD, and PD-spectrum disease rel 2.10

tau, seeded biosensor activity, EV-associated tau release, and synaptic

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Wiki Validated Hypothesis: Microglial Senescence Prevention via TREM2/SASP Axis rel 2.10

tau phosphorylation in tau transgenic backgrounds. Conversely, cystatin-C overexpression

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Wiki Validated Hypothesis: Circadian Glymphatic Entrainment via Targeted Orexin Receptor Modulation rel 2.00

tau transgenic mice increases tau spreading and pathology burden - Orexin

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Wiki Validated Hypothesis: Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocampal gamma oscillations via upstream perforant path gating in Alzheimer's disease rel 1.80

tau mouse model, tau pathology was sufficient to produce excitatory

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Wiki Validated Hypothesis: APOE-Dependent Autophagy Restoration rel 1.80

TAU[" up p-Tau Accumulation"] CATH --> AB CATH --> TAU AUTO

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Wiki Validated Hypothesis: Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST interneurons to restore hippocampal-prefrontal synchrony in early AD rel 1.70

tau mouse model, tau pathology was sufficient to produce excitatory

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Wiki Validated Hypothesis: Gamma Oscillation Enhancement Synergy rel 1.60

tau transgenic lines (PS19 or rTg4510) showed accelerated tau pathology

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Wiki Validated Hypothesis: Mitochondrial DAMPs-Driven AIM2 Inflammasome Activation in Neurodegeneration rel 1.30

tau treatments may provide synergistic neuroprotective effects by simultaneously addressing

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Wiki Validated Hypothesis: Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 Proteinopathy Neuroinflammation in ALS/FTD rel 1.30

tau provide downstream measures of neurodegeneration that should decrease with

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Wiki Validated Hypothesis: Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via direct PV interneuron recruitment in Alzheimer's disease rel 1.30

tau pathology in 5XFAD and tau P301S mice - **[PMID: 35151204]** (high

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Wiki Validated Hypothesis: Closed-loop optogenetic targeting PV interneurons to restore theta-gamma coupling and prevent amyloid-induced synaptic dysfunction in AD rel 1.20

tau pathology in 5XFAD and tau P301S mice. Identifier 31076275. This

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Wiki Validated Hypothesis: Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming in Neurodegeneration rel 1.20

tau phosphorylation, while IL-1β neutralization prevents gut permeability-associated

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Wiki Validated Hypothesis: Optogenetic restoration of hippocampal gamma oscillations via selective PV interneuron activation using implantable LED arrays in Alzheimer's disease rel 1.20

tau pathology in 5XFAD and tau P301S mice. Identifier 31076275. This

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Wiki Validated Hypothesis: Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-Synuclein Aggregates Drives Non-Cell-Autonomous Neurodegeneration rel 1.20

tau) to capture the downstream neuroprotective effects of inflammasome inhibition

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Wiki Validated Hypothesis: Thalamocortical Feedforward Inhibition Imposes Rhythm on Glymphatic Waste Clearance Windows rel 1.10

tau disruption vs. rhythm reduction accelerating tau *([PMID:N/A](https://pubmed.ncbi.nlm.nih.gov

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Wiki Validated Hypothesis: Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Release Mechanism for AIM2 Inflammasome Activation in Neurodegeneration rel 1.10

tau-mediated ER stress, and the chronic neuroinflammation that drives

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Wiki Validated Hypothesis: Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via cholecystokinin interneuron neuromodulation in Alzheimer's disease rel 1.10

tau pathology in 5XFAD and tau P301S mice. Identifier 31076275. This

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Wiki Validated Hypothesis: Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via glymphatic enhancement and amyloid clearance from PV interneurons in Alzheimer's disease rel 1.10

tau pathology in 5XFAD and tau P301S mice. Identifier 31076275. This

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Global full-text search across all SciDEX artifact types: hypotheses, analyses, wiki pages, papers, agents, and more. Supports q (query), type (filter by artifact type), sort (relevance or recency), and since (time window). Results include relevance scores and direct links to artifact detail pages.

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